ArticleJournal of cerebrovascular and endovascular neurosurgery2021
Association of Parkinson's disease with ischemic stroke in Korea: A nationwide longitudinal cohort study in Korea.
Article in Journal of cerebrovascular and endovascular neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Exploring patterns of multimorbidity in South Korea using exploratory factor analysis and non negative matrix factorization.Scientific reports · 2025Article
- Risk of Parkinson disease in stroke patients: A nationwide cohort study in South Korea.European journal of neurology · 2024Article
- The Association between Parkinson's Disease and Congestive Heart Failure in Korea: A Nationwide Longitudinal Cohort Study.Journal of personalized medicine · 2023Article
- Stroke in Parkinson's disease: a review of epidemiological studies and potential pathophysiological mechanisms.Acta neurologica Belgica · 2023Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this nationwide age- and sex- matched longitudinal follow up study is to determine the risk of Parkinson's disease (PD) associated with ischemic stroke in Korea.
methodsPatient data were collected from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS). PD was identified using the International Classification of Diseases (ICD) 10-CM code G 20. In total, 6,475 patients were enrolled in the PD group from the NHISS. After subtracting 1,039 patients who underwent hospitalization less than once or those who visited an outpatient clinic less than two times, 5,259 patients who were diagnosed after January 1, 2004 ultimately participated in this study. After case-control match was done through 1:5 age- and sex- stratified matching, 26,295 individuals were chosen as control. Kaplan-Meier method and Cox proportional hazard regression analysis were performed to evaluate the risk of ischemic stroke in PD.
resultsThe hazard ratio of ischemic stroke in the PD group was 3.848 (95% confidence interval (confidence interval [CI]): 3.14-4.70) after adjusting for age and sex. The adjusted hazard ratio of ischemic stroke in PD group was 3.885 (95% CI: 3.17-4.75) after adjusting for comorbidities. According to subgroup analysis, in male and female and non-diabetes and diabetes and non-hypertension and hypertension and dyslipidemia and non-dyslipidemia subgroups, ischemic stroke incidence rates were significantly higher in the PD group than those in the control group.
conclusionsThis nationwide longitudinal study suggests an increased risk of ischemic stroke in PD patients.
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