ArticleKidney research and clinical practice2021
Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea.
Article in Kidney research and clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.
- Pediatric rhabdomyolysis: a systematic review and meta-analysis of etiologies, management, and outcomes.BMC pediatrics · 2025Pooled it
- Uric acid in predicting the traumatic rhabdomyolysis induced acute kidney injury; a systematic review and meta-analysis.BMC nephrology · 2024Pooled it
- Creatine Kinase as a Prognostic Factor for Mortality in Extracorporeal Cardiopulmonary Resuscitation: A Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Debunking myths: sickle cell trait, crises, and sudden death.Blood advances · 2025Article
- Rhabdomyolysis in Children: A State-of-the-Art Review.Children (Basel, Switzerland) · 2025Review
- Acute Kidney Injury in Rhabdomyolysis: A 5-Year Children's Hospital Network Study.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Clinical features of dengue-associated myositis in children: a retrospective study.Jornal de pediatriaObservational
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Authors and funding
30 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multicenter studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis and reveal the risk factors for acute kidney injury (AKI) in such cases.
methodsThis retrospective study analyzed the medical records of children and adolescents diagnosed with rhabdomyolysis at 23 hospitals in South Korea between January 2007 and December 2016.
resultsAmong 880 patients, those aged 3 to 5 years old composed the largest subgroup (19.4%), and all age subgroups were predominantly male. The incidence of AKI was 11.3%. Neurological disorders (53.6%) and infection (39.0%) were the most common underlying disorder and cause of rhabdomyolysis, respectively. The median age at diagnosis in the AKI subgroup was older than that in the non-AKI subgroup (12.2 years vs. 8.0 years). There were no significant differences in body mass index, myalgia, dark-colored urine, or the number of causal factors between the two AKI-status subgroups. The multivariate logistic regression model indicated that the following factors were independently associated with AKI: multiorgan failure, presence of an underlying disorder, strong positive urine occult blood, increased aspartate aminotransferase and uric acid levels, and reduced calcium levels.
conclusionsOur study revealed characteristic clinical and laboratory features of rhabdomyolysis in a Korean pediatric population and highlighted the risk factors for AKI in these cases. Our findings will contribute to a greater understanding of pediatric rhabdomyolysis and may enable early intervention against rhabdomyolysis-induced AKI.
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