Evidence map›Paper›PMID 34510818›Full record

ArticleFEBS open bio2022

The crystal structure of MreC provides insights into polymer formation.

Qin Xu, Ning Sun, Qingjie Xiao, Chia-Ying Huang, Mengxue Xu, Weizhe Zhang, Lina Li, Qisheng Wang, Vincent Olieric, Weiwu Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Qin XuShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Ning SunShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Qingjie XiaoShanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Chia-Ying HuangSwiss Light Source, Paul Scherrer Institute, Villigen-PSI, Switzerland.
Mengxue XuShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Weizhe ZhangShanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Lina LiShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Qisheng WangShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Vincent OliericSwiss Light Source, Paul Scherrer Institute, Villigen-PSI, Switzerland.
Weiwu WangDepartment of Microbiology, College of Life Sciences, Nanjing Agricultural University, China.
Jianhua HeShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Bo SunShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-1932-2267
Chinese Academy of Sciences · CNNanjing Agricultural University · CNPaul Scherrer Institute · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MreC is a scaffold protein required for cell shape determination through interactions with proteins related to cell wall synthesis. Here, we determined the crystal structure of the major periplasmic part of MreC from Escherichia coli at 2.1 Å resolution. The periplasmic part of MreC contains a coiled-coil domain and two six-stranded barrel domains. The coiled-coil domain is essential for dimer formation, and the two monomers are prone to relative motion that is related to the small interface of β-barrel domains. In addition, MreC forms an antiparallel filament-like structure along the coiled-coil direction, which is different from the helical array structure in Pseudomonas aeruginosa. Our structure deepens our understanding of polymer formation of MreC.

Indexed as

Bacterial ProteinsPolymersProtein DomainsPseudomonas aeruginosaBacterial ProteinsPolymerscell shape-determining proteincrystal structurefilament-like structureMreCpolymer formation

Identifiers

PMID34510818
PMCPMC8804602
OpenAlexW3200711599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.