Evidence map›Paper›PMID 34510772›Full record

ArticleJournal of separation science2021

Phytometabolite profiling of Coronil, a herbal medicine for COVID-19, its identification by mass-spectroscopy and quality validation on liquid chromatographic platforms.

Acharya Balkrishna, Meenu Tomer, Sudeep Verma, Monali Joshi, Priyanka Sharma, Jyotish Srivastava, Anurag Varshney

Open access · bronzeAbstract readValidation Study
In one paragraph

Article in Journal of separation science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Penta-O-Galloyl-Frontiers in pharmacology · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Acharya BalkrishnaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand, 249405, India.
Meenu TomerDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand, 249405, India.
Sudeep VermaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand, 249405, India.
Monali JoshiDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand, 249405, India.
Priyanka SharmaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand, 249405, India.
Jyotish SrivastavaDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand, 249405, India.
Anurag VarshneyDrug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar, Uttarakhand, 249405, India.ORCID https://orcid.org/0000-0001-8509-0882
Patanjali Research Foundation · INJawaharlal Nehru University · IN

Funding

Patanjali Research Foundation Trust, Haridwar, India
6 · The paper itself

Abstract

Coronil is a tri-herbal medicine consisting of immunomodulatory herbs, Withania somnifera, Tinospora cordifolia, and Ocimum sanctum. The formulation has been developed specifically as the supporting measure for COVID-19. Current investigation is aimed to identify the phytoconstituents in Coronil utilizing ultra-performance liquid chromatography-mass spectrometry coupled with quadrapole time of flight and to establish its quality standardization using high-performance liquid chromatography and high performance thin layer chromatography. Out of 52 identified compounds, cordifolioside A, magnoflorine, rosmarinic acid, palmatine, withanoside IV, withanoside V, withanone, betulinic acid, and ursolic acid were quantified in 15 different batches of Coronil on validated high-performance liquid chromatography method. Similarly, withanoside IV, withaferin A, magnoflorine, palmatine, rosmarinic acid, and ursolic acid were analyzed on high performance thin layer chromatography. Methods were validated as per the International Council for Harmonization guidelines. These methods were specific, reproducible, accurate, precise, linear (r

Indexed as

COVID-19 Drug TreatmentHerbal MedicineChromatography, High Pressure LiquidChromatography, Thin LayerCOVID-19HumansMass SpectrometryPhytochemicalsQuality ControlSARS-CoV-2Spectroscopy, Fourier Transform InfraredPhytochemicalsayurvedaCoronilliquid chromatographymass spectrometryvalidation

Identifiers

PMID34510772
PMCPMC8661915
OpenAlexW3200101101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.