Evidence map›Paper›PMID 34510696›Full record

ReviewJournal of midwifery & women's health2021

Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment.

Jessica A Pettigrew, Andrew M Novick

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Journal of midwifery & women's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07152847 (Developing a Psychosexual Education App With Artificial Intelligence for National Health Service Patients on a Psychosexual Services Waiting List), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07152847 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Developing a Psychosexual Education App With Artificial Intelligence for National Health Service Patients on a Psychosexual Services Waiting List: A Pilot Pre Test Post Test Study

TypeinterventionalSponsorLondon Metropolitan UniversityRan2026 to 2027Enrolled150ConditionsSexual DysfunctionArmsPsychosexual education app with artificial intelligence
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Optimising testosterone therapy in patients with hypoactive sexual desire disorder.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Article
  6. Article
  7. The role of sexual self-esteem, sexual desire, and sexual assertiveness in the female sexual function.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2024
    Article
  8. Article
  9. Challenges of prescribing testosterone for sexual dysfunction in women: Number 7 - 2024.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Article
  10. Review
  11. Testosterone: Vital to female physiology.Women's health (London, England)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jessica A PettigrewDepartment of Obstetrics & Gynecology, University of Colorado School of Medicine-Anschutz Medical Campus, Aurora, Colorado.
Andrew M NovickDepartment of Psychiatry, University of Colorado School of Medicine-Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0002-0995-5060
University of Colorado Anschutz Medical Campus · US

Funding

Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 2018 to 2026
$13.5M
Center for Women's Health Research, University of Colorado Junior Faculty Research AwardNIA NIH HHS U54 AG062319NIA NIH HHS U54AG062319
6 · The paper itself

Abstract

Nearly half of women in the United States report problems with sexual function. Many health care providers do not ask about sexual concerns during routine clinical encounters because of personal discomfort, lack of familiarity with treatment, or the belief that they lack adequate time to address this complex issue. This may be especially true for hypoactive sexual desire disorder (HSDD), the most commonly identified sexual problem among women. HSDD is characterized by a deficiency of sexual thoughts, feelings, or receptiveness to sexual stimulation that has been present for at least 6 months, causes personal distress, and is not due to another medical condition. This is an up-to-date overview of HSDD for clinicians, discussing its physiology, assessment, diagnosis, and treatment strategies. Although a definitive physiology of HSDD is still unknown, multiple hormones and neurotransmitters likely participate in a dual-control model to balance excitation and inhibition of sexual desire. For assessment and diagnosis, validated screening tools are discussed, and the importance of a biopsychosocial assessment is emphasized, with guidance on how this can be implemented in clinical encounters. The 2 recently approved medications for HSDD, flibanserin and bremelanotide, are reviewed as well as off-label treatments. Overall, HSDD represents a common yet likely underrecognized disorder that midwives and other health care providers who care for women across the life span are in a unique position to address.

Indexed as

MidwiferySexual Dysfunctions, PsychologicalFemaleHumansPregnancyhypoactive sexual desire disorderlibidosexual desiresexual dysfunctionwomen's health

Identifiers

PMID34510696
PMCPMC8673442
OpenAlexW3200764508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.