Evidence map›Paper›PMID 34510403›Full record

ArticleDermatology and therapy2021

Practical Management of Patients with Atopic Dermatitis on Dupilumab.

Kim A Papp, Chih-Ho Hong, M Perla Lansang, Irina Turchin, David N Adam, Jennifer R Beecker, Robert Bissonnette, Melinda J Gooderham, Carolyn Jack, Marissa Joseph and 2 more

Abstract read
In one paragraph

Article in Dermatology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kim A PappProbity Medical Research, Waterloo, ON, Canada. kapapp@probitymedical.com.ORCID http://orcid.org/0000-0001-9557-3642
Chih-Ho HongProbity Medical Research, Waterloo, ON, Canada.
M Perla LansangDivision of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Irina TurchinProbity Medical Research, Waterloo, ON, Canada.
David N AdamProbity Medical Research, Waterloo, ON, Canada.
Jennifer R BeeckerProbity Medical Research, Waterloo, ON, Canada.
Robert BissonnetteInnovaderm Research, Montreal, QC, Canada.
Melinda J GooderhamProbity Medical Research, Waterloo, ON, Canada.
Carolyn JackDivision of Dermatology, McGill University, Montreal, QC, Canada.
Marissa JosephDivision of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Charles W LyndeProbity Medical Research, Waterloo, ON, Canada.
Neil H ShearDivision of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDupilumab is approved to treat moderate-to-severe atopic dermatitis (AD) in several countries in patients as young as 6 years of age. Since its approval, practical issues related to the use of dupilumab for AD have arisen, with particular interest in transitioning from current therapies and managing medication overlap, considerations for special populations of patients with AD, and management of potential adverse events.

methodsThis article aims to review the literature addressing several practical management issues related to dupilumab use for AD and to provide a framework for clinical decision-making in these circumstances and sub-populations. Each statement was reviewed, revised and voted on by authors to provide their level of agreement and degree of uncertainty for each statement.

resultsAn agreement level > 80% was achieved for all of the statements.

conclusionThe expert panel provides statements considering the practical management of patients with AD taking dupilumab to inform clinical decision-making in specific but frequently encountered clinical situations.

Indexed as

Atopic dermatitisDupilumabPractical management

Identifiers

PMID34510403
PMCPMC8435113

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.