Evidence map›Paper›PMID 34510367›Full record

ArticleVirologica Sinica2021

α-Lipoic Acid Exerts Its Antiviral Effect against Viral Hemorrhagic Septicemia Virus (VHSV) by Promoting Upregulation of Antiviral Genes and Suppressing VHSV-Induced Oxidative Stress.

Wanwan Zhang, Xiaoqi Chen, Fangzhao Yu, Fengquan Li, Wangdong Li, Meisheng Yi, Kuntong Jia

Open access · bronzeAbstract read
In one paragraph

Article in Virologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Role of Lipoic Acid in Testosterone Production in Males.The world journal of men's health · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wanwan ZhangSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510275, China.
Xiaoqi ChenSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510275, China.
Fangzhao YuModern Agricultural Development Center of Zhuhai City, Zhuhai, 519000, China.
Fengquan LiSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510275, China.
Wangdong LiModern Agricultural Development Center of Zhuhai City, Zhuhai, 519000, China.
Meisheng YiSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510275, China. yimsh@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-1794-2734
Kuntong JiaSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510275, China. jiakt3@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-7674-9454
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral hemorrhagic septicemia virus (VHSV), belonging to the genus Novirhabdovirus, Rhabdoviridae family, is a causative agent of high mortality in fish and has caused significant losses to the aquaculture industry. Currently, no effective vaccines, Food and Drug Administration-approved inhibitors, or other therapeutic intervention options are available against VHSV. α-Lipoic Acid (LA), a potent antioxidant, has been proposed to have antiviral effects against different viruses. In this study, LA (CC

Indexed as

Antiviral AgentsFish DiseasesNovirhabdovirusOxidative StressThioctic AcidAnimalsCells, CulturedCyprinidaeUp-RegulationAntiviral AgentsThioctic AcidAntiviralIFN responseOxidative stressViral hemorrhagic septicemia virus (VHSV)α-Lipoic acid (LA)

Identifiers

PMID34510367
PMCPMC8435143
OpenAlexW3199567125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.