Evidence map›Paper›PMID 34510320›Full record

ArticleMolecular biology reports2021

ADA gene haplotype is associated with coronary-in-stent-restenosis.

Morteza Gholami, Sepideh Borhan Dayani, Maryam Mehrpooya, Mahsa M Amoli

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Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Morteza GholamiMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Sepideh Borhan DayaniEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Maryam MehrpooyaInterventional Cardiology Department, Tehran University of Medical Sciences, Tehran, Iran.
Mahsa M AmoliMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. amolimm@tums.ac.ir.ORCID http://orcid.org/0000-0002-9168-9223

Funding

National Institute for Medical Research Development 987686
6 · The paper itself

Abstract

backgroundCardiovascular diseases (CVDs) are the most common and the first cause of death worldwide. While some studies have investigated the association of the Adenosine Deaminase (ADA) gene with CDVs, its roles on in-stent restenosis (ISR) has not been studied. METHODS AND

resultsIn this study, we investigated the role of ADA gene variants in both genetic and haplotype models on the risk of ISR. 91 samples were included in this study. The subjects were divided into two groups regarding having or not-having ISR (n = 40 ISR+ and n = 51 ISR-). The genotyping for G22A (rs73598374) and A4223C (rs452159) polymorphisms was performed using PCR-RFLP method. Statistical analysis was performed by SPSS v. 20 and Haploview 4.2 softwares. The basic demographic conditions in ISR groups were statistically similar. There was a significant association between A allele of rs452159 ISR groups after adjustment (allelic model: P value = 0.028, OR(95%CI) = 0.366(0.149-0.899)), while rs73598374 polymorphism shows no significant association with ISR. In haplotype analysis, the GA (G:rs73598374/A:rs452159) haplotype decreased the risk of ISR (P value = 00.025, OR(95%CI) = 0.382(0.161-0.907)).

conclusionsThis study suggests that A allele of ADA rs452159 polymorphism and GA (G:rs73598374/A:rs452159) haplotype may be related to decreased risk of ISR in CAD patients receiving drug-eluting stent and offers more observational studies on ADA variants in other populations to generate a potential haplotype panel for ISR risk assessment.

Indexed as

Adenosine DeaminaseCoronary RestenosisFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsStentsADA protein, humanAdenosine DeaminaseAdenosine deaminaseCardiovascular diseasesHaplotypeIn-stent restenosisPolymorphism

Identifiers

PMID34510320

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