Evidence map›Paper›PMID 34510196›Full record

Trial reportSchizophrenia bulletin2022

Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.

Rachel Loewy, Melissa Fisher, Sisi Ma, Cameron Carter, J Daniel Ragland, Tara A Niendam, Barbara Stuart, Danielle Schlosser, Felix Amirfathi, Seghel Yohannes and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  18. The MATRICS Consensus Cognitive Battery: An Update.Current topics in behavioral neurosciences · 2023
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rachel LoewyDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Melissa FisherDepartment of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Sisi MaSchool of Medicine, Division of General Internal Medicine, University of Minnesota, Minneapolis, MN, USA.
Cameron CarterDepartment of Psychiatry, University of California, Davis, Davis, CA, USA.
J Daniel RaglandDepartment of Psychiatry, University of California, Davis, Davis, CA, USA.
Tara A NiendamDepartment of Psychiatry, University of California, Davis, Davis, CA, USA.
Barbara StuartDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Danielle SchlosserDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Felix AmirfathiDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Seghel YohannesDepartment of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Sophia VinogradovDepartment of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Using a computational and network neuroscience framework to study pharmacological manipulations of state representation processes in early psychosisP50MH119569 · NIMH · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH, Sophia Vinogradov · 2020 to 2026
$24.5M
Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisR01MH081051 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI VINOGRADOV, SOPHIA · 2008 to 2012
$2.4M
Cognition Trajectories in Cognitive Training and Early Intervention Treatment Programs in SchizophreniaR03MH117254 · NIMH · UNIVERSITY OF MINNESOTA · PI VINOGRADOV, SOPHIA · 2019 to 2020
$154k
NCATS NIH HHS UL1 TR002494NIMH NIH HHS P50 MH119569NIMH NIH HHS R01 MH081051NIMH NIH HHS R03 MH117254
6 · The paper itself

Abstract

objectiveCognitive impairment in schizophrenia predicts functional outcomes and is largely unresponsive to pharmacology or psychotherapy; it is thus a critical unmet treatment need. This article presents the impact of remotely completed, intensive, targeted auditory training (AT) vs control condition computer games (CG) in a double-blind randomized trial in young adults with recent-onset schizophrenia.

methodParticipants (N = 147) were assessed for cognition, symptoms, and functioning at baseline, post-intervention, and at 6-month follow-up. All participants were provided with laptop computers and were instructed to complete 40 hours remotely of training or computer games. An intent-to-treat analysis (N = 145) was performed using linear mixed models with time modeled as a continuous variable. Planned contrasts tested the change from baseline to post-training, baseline to 6-month follow-up, and post-training to 6-month follow-up.

resultsGlobal Cognition, which had improved in the AT group relative to the CG group at post-training, showed durable gains at 6-month follow-up in an omnibus group-by-time interaction test (F(1,179) = 4.80, P = .030), as did Problem-Solving (F(1,179) = 5.13, P = .025), and Speed of Processing improved at trend level significance (F(1,170) = 3.80, P = .053). Furthermore, the AT group showed significantly greater improvement than the CG group in positive symptoms (F(1,179) = 4.06, P = .045).

conclusionsThese results provide the first evidence of durable cognitive gains and symptom improvement at follow-up of cognitive training (CT) in early schizophrenia completed independently and remotely. While functioning did not show significant improvement, these findings suggest that intensive targeted CT of auditory processing is a promising component of early intervention to promote recovery from psychosis.

Indexed as

Cognitive RemediationAdultCognitive DysfunctionDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleOutcome Assessment, Health CarePsychotic DisordersSchizophreniaYoung Adultcognitive remediationcognitive trainingfirst-episode psychosisrecent-onset psychosis

Identifiers

PMID34510196
PMCPMC8781343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.