Evidence map›Paper›PMID 34510000›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2021

Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease.

Anna Sauerbier, Philipp Loehrer, Stefanie T Jost, Shania Heil, Jan N Petry-Schmelzer, Johanna Herberg, Pia Bachon, Salima Aloui, Alexandra Gronostay, Lisa Klingelhoefer and 12 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 6 countries.

Anna SauerbierInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK anna.2.sauerbier@kcl.ac.uk haidar.dafsari@uk-koeln.de.ORCID 0000-0003-0966-5933
Philipp LoehrerDepartment of Neurology, University of Marburg and University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany.
Stefanie T JostDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID 0000-0003-0477-2289
Shania HeilDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Jan N Petry-SchmelzerDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID 0000-0003-0749-3840
Johanna HerbergDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Pia BachonDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Salima AlouiDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Alexandra GronostayDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Lisa KlingelhoeferDeptartment of Neurology, University of Dresden and University Hospital Dresden, Dresden, Germany.
J Carlos BaldermannDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID 0000-0001-5851-9268
Daniel HuysDepartment of Psychiatry, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID 0000-0002-9124-4128
Christopher NimskyDepartment of Neurosurgery, University of Marburg and University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany.
Michael T BarbeDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Gereon R FinkDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Pablo Martinez-MartinCenter for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain.
K Ray ChaudhuriInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Veerle Visser-VandewalleDepartment of Stereotaxy and Functional Neurosurgery, University of Cologne and University Hospital Cologne, Cologne, Germany.
Lars TimmermannDepartment of Neurology, University of Marburg and University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany.
Daniel WeintraubDepartments of Psychiatry and Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Haidar S DafsariDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany anna.2.sauerbier@kcl.ac.uk haidar.dafsari@uk-koeln.de.ORCID 0000-0001-8849-4233
EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson's Disease Study Group
University of Cologne · DEUniversitätsklinikum Gießen und Marburg · DEForschungszentrum Jülich · DEInstituto de Salud Carlos III · ESKing's College London · GBUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson's disease (PD) are understudied.

objectiveTo investigate clinical predictors of STN-DBS effects on ICB.

methodsIn this prospective, open-label, multicentre study in patients with PD undergoing bilateral STN-DBS, we assessed patients preoperatively and at 6-month follow-up postoperatively. Clinical scales included the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS), PD Questionnaire-8, Non-Motor Symptom Scale (NMSS), Unified PD Rating Scale in addition to levodopa-equivalent daily dose total (LEDD-total) and dopamine agonists (LEDD-DA). Changes at follow-up were analysed with Wilcoxon signed-rank test and corrected for multiple comparisons (Bonferroni method). We explored predictors of QUIP-RS changes using correlations and linear regressions. Finally, we dichotomised patients into 'QUIP-RS improvement or worsening' and analysed between-group differences.

resultsWe included 55 patients aged 61.7 years±8.4 with 9.8 years±4.6 PD duration. QUIP-RS cut-offs and psychiatric assessments identified patients with preoperative ICB. In patients with ICB, QUIP-RS improved significantly. However, we observed considerable interindividual variability of clinically relevant QUIP-RS outcomes as 27.3% experienced worsening and 29.1% an improvement. In post hoc analyses, higher baseline QUIP-RS and lower baseline LEDD-DA were associated with greater QUIP-RS improvements. Additionally, the 'QUIP-RS worsening' group had more severe baseline impairment in the NMSS attention/memory domain.

conclusionsOur results show favourable ICB outcomes in patients with higher preoperative ICB severity and lower preoperative DA doses, and worse outcomes in patients with more severe baseline attention/memory deficits. These findings emphasise the need for comprehensive non-motor and motor symptoms assessments in patients undergoing STN-DBS. TRIAL REGISTRATION NUMBER: DRKS00006735.

Indexed as

Deep Brain StimulationAgedCompulsive BehaviorFemaleHumansImpulsive BehaviorMaleMiddle AgedParkinson DiseaseProspective StudiesQuality of LifeSubthalamic Nucleus

Identifiers

PMID34510000
PMCPMC8606469
OpenAlexW3201277512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.