Evidence map›Paper›PMID 34509578›Full record

ArticleToxicology2021

Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta).

Ji-Eun Seo, Kelly Davis, Pritpal Malhi, Xiaobo He, Matthew Bryant, John Talpos, Susan Burks, Nan Mei, Xiaoqing Guo

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ji-Eun SeoDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Kelly DavisToxicologic Pathology Associates, Jefferson, AR 72079, USA.
Pritpal MalhiToxicologic Pathology Associates, Jefferson, AR 72079, USA.
Xiaobo HeOffice of Scientific Coordination, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Matthew BryantOffice of Scientific Coordination, National Center for Toxicological Research, Jefferson, AR 72079, USA.
John TalposDivision of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Susan BurksDivision of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Nan MeiDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Xiaoqing GuoDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Electronic address: Xiaoqing.Guo@fda.hhs.gov.
National Center for Toxicological Research · US

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Non-human primates (NHPs) have played a vital role in fundamental, pre-clinical, and translational studies because of their high physiological and genetic similarity to humans. Here, we report a method to isolate primary hepatocytes from the livers of rhesus macaques (Macaca mulatta) after in situ whole liver perfusion. Isolated primary macaque hepatocytes (PMHs) were treated with various compounds known to have different pathways of genotoxicity/carcinogenicity and the resulting DNA damage was evaluated using the high-throughput CometChip assay. The comet data were quantified using benchmark dose (BMD) modeling and the BMD

Indexed as

AnimalsBenchmarkingCarcinogensCytochrome P-450 Enzyme SystemDNA DamageDose-Response Relationship, DrugHepatocytesHigh-Throughput Screening AssaysHumansMacaca mulattaMaleMutagensReproducibility of ResultsSpecies SpecificityCarcinogensCytochrome P-450 Enzyme SystemMutagensBenchmark doseComet assayGenotoxicityNon-human primatePrimary hepatocyte

Identifiers

PMID34509578
PMCPMC12412453
OpenAlexW3199100390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.