ReviewPharmacology, biochemistry, and behavior2021
What was learned from studying the effects of early institutional deprivation.
Review in Pharmacology, biochemistry, and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Intergenerational Effects of Stress - A Focus on Learning and Memory.Current topics in behavioral neurosciences · 2025Review
- Strengthening through adversity: The hormesis model in developmental psychopathology.Development and psychopathology · 2024Article
- Impacts of early deprivation on behavioral and neural measures of executive function in early adolescence.Brain and cognition · 2024Article
- Helping Institutionalised Children through a Trusting Relationship-Findings from a One-Year Psychosocial Intervention Programme.Behavioral sciences (Basel, Switzerland) · 2024Article
- Lingering Effects of Early Institutional Rearing and Cytomegalovirus Infection on the Natural Killer Cell Repertoire of Adopted Adolescents.Biomolecules · 2024Article
- Early childhood deprivation and the impact of negative life events on mental health in later life: a test of the stress sensitization hypothesis.Frontiers in psychiatry · 2024Article
- Earlier pubertal timing, not tempo, links time-limited early adversity with psychopathology.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The effect of experiences in infancy on human development is a central question in developmental science. Children raised in orphanage-like institutions for their first year or so of life and then adopted into well-resourced and supportive families provide a lens on the long-term effects of early deprivation and the capacity of children to recover from this type of early adversity. While it is challenging to identify cause-and-effect relations in the study of previously institutionalized individuals, finding results that are consistent with animal experimental studies and the one randomized study of removal from institutional care support the conclusion that many of the outcomes for these children were induced by early institutional deprivation. This review examines the behavioral and neural evidence for altered executive function, declarative memory, affective disorders, reward processing, reactivity to threat, risk-taking and sensation-seeking. We then provide a brief overview of the neurobiological mechanisms that may transduce early institutional experiences into effects on brain and behavior. In addition, we discuss implications for policy and practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.