Evidence map›Paper›PMID 34509496›Full record

ReviewNeuropharmacology2021

RNA aptamers for AMPA receptors.

Zhen Huang, Li Niu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective.International journal of molecular sciences · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Zhen HuangChemistry Department, Center for Neuroscience Research, University at Albany, State University of New York (SUNY), Albany, NY, USA.
Li NiuChemistry Department, Center for Neuroscience Research, University at Albany, State University of New York (SUNY), Albany, NY, USA. Electronic address: lniu@albany.edu.
Albany State University · USUniversity at Albany, State University of New York · US

Funding

Mechanistic studies of the GYKI CompoundsR01NS060812 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI NIU, LI · 2009 to 2013
$1.5M
Testing RNA Aptamers in ALS Mouse ModelsR21NS106392 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI NIU, LI · 2018 to 2019
$406k
NINDS NIH HHS R01 NS060812NINDS NIH HHS R21 NS106392
6 · The paper itself

Abstract

RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors, are potential drug candidates for treatment of a number of CNS diseases that involve excessive receptor activation and/or elevated receptor expression. Here we review the approach to discover RNA aptamers targeting AMPA receptors from a random sequence library (∼10

Indexed as

AnimalsAptamers, NucleotideCentral Nervous System DiseasesHumansReceptors, AMPAAptamers, NucleotideReceptors, AMPAAMPA receptorsCNS diseases And disordersDrug developmentKainate receptorsRNA aptamers

Identifiers

PMID34509496
PMCPMC9284364
OpenAlexW3200429438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.