Evidence map›Paper›PMID 34509495›Full record

ArticleNeuropharmacology2021

Modulation of relapse-like drinking in male Sprague-Dawley rats by ligands targeting the α5GABA

Cassie M Chandler, Jaren Reeves-Darby, Sherman A Jones, Guanguan Li, Md T Rahman, James M Cook, Donna M Platt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. GABAergic compounds for the treatment of alcohol use disorder.International review of neurobiology · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cassie M ChandlerGraduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Jaren Reeves-DarbyGraduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Sherman A JonesDepartment of Psychiatry & Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Guanguan LiDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
Md T RahmanDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
James M CookDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
Donna M PlattGraduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA; Department of Psychiatry & Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA. Electronic address: dplatt@umc.edu.
University of Mississippi Medical Center · USUniversity of Wisconsin–Milwaukee · US

Funding

Center for Psychiatric NeuroscienceP30GM103328 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI STOCKMEIER, CRAIG ALLEN · 2013 to 2017
$5.5M
GABAa receptor subtype mechanisms in nonhuman primatesR01AA016179 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2006 to 2016
$3.2M
GABA-A receptor subtype mechanisms and the abuse-related effects of alcoholR01AA029023 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2020 to 2024
$2.4M
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
NIAAA NIH HHS R01 AA016179NIAAA NIH HHS R01 AA029023NIGMS NIH HHS P30 GM103328NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

Preclinical evidence suggests a key role for GABA

Indexed as

Alcohol DrinkingAlcoholismAnimalsBehavior, AnimalBenzodiazepinesDisease Models, AnimalGABA-A Receptor AgonistsImidazolesLigandsMaleRatsRats, Sprague-DawleyReceptors, GABA-ARecurrenceBenzodiazepinesGABA-A Receptor AgonistsGabra5 protein, ratImidazolesL 655,708LigandsQH-II-66Receptors, GABA-AAlcohol deprivation effectEthanolGABA(A) receptorsPharmacotherapyRelapse

Identifiers

PMID34509495
PMCPMC8511242
OpenAlexW3197323646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.