Evidence map›Paper›PMID 34509466›Full record

ArticleChemistry and physics of lipids2021

Monitoring the cellular metabolism of a membrane-permeant photo-caged phosphatidylinositol 3,4,5-trisphosphate derivative.

Mevlut Citir, Rainer Müller, Sebastian Hauke, Alexis Traynor-Kaplan, Carsten Schultz

Abstract read
In one paragraph

Article in Chemistry and physics of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Lipid probes to study ion channels.Current opinion in chemical biology · 2025
    Review
  2. Review
  3. Chemical Tools for Lipid Cell Biology.Accounts of chemical research · 2023
    Article
  4. Review
  5. Cyclic Nucleotide (cNMP) Analogues: Past, Present and Future.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mevlut CitirEuropean Molecular Biology Laboratory (EMBL), Cell Biology & Biophysics Unit, Meyerhofstraße 1, 69117, Heidelberg, Germany. Electronic address: mevcit@gmail.com.
Rainer MüllerEuropean Molecular Biology Laboratory (EMBL), Cell Biology & Biophysics Unit, Meyerhofstraße 1, 69117, Heidelberg, Germany. Electronic address: rmueller@embl.de.
Sebastian HaukeEuropean Molecular Biology Laboratory (EMBL), Cell Biology & Biophysics Unit, Meyerhofstraße 1, 69117, Heidelberg, Germany. Electronic address: sebastian.hauke89@gmx.de.
Alexis Traynor-KaplanATK Innovation, Analytics and Discovery, North Bend, WA, 98045, USA; University of Washington, Department of Medicine, Seattle, WA, 98195, USA. Electronic address: atkaplan@u.washington.edu.
Carsten SchultzEuropean Molecular Biology Laboratory (EMBL), Cell Biology & Biophysics Unit, Meyerhofstraße 1, 69117, Heidelberg, Germany; Oregon Health & Science University (OHSU), Department of Chemical Physiology and Biochemistry, L334 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA. Electronic address: schulcar@ohsu.edu.

Funding

Chemical biology tools for studying growth factor receptor internalizationR01GM127631 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHULTZ, CARSTEN · 2018 to 2024
$2.4M
NIGMS NIH HHS R01 GM127631
6 · The paper itself

Abstract

To deliver charged lipid derivatives to the cell interior, bioactivatable and photo-activatable protecting groups are frequently used. The intracellular metabolism of the protecting groups, as well as the lipid itself, are key factors that determine biological activity. Here we followed the cellular metabolism of cell-permeant photo-activatable ("caged") and non-caged membrane-permeant analogs of dioctanoyl phosphatidylinositol 3,4,5-trisphosphate (diC

Indexed as

HeLa CellsHumansPhosphatidylinositol PhosphatesTumor Cells, Culturedphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol PhosphatesMass spectrometryMulti-reaction monitoringPhosphoinositidesPhotoactivatable groupsProtecting groups

Identifiers

PMID34509466
PMCPMC11364432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.