Evidence map›Paper›PMID 34508917›Full record

ReviewAutoimmunity reviews2021

Autoimmunity roots of the thrombotic events after COVID-19 vaccination.

Fatma Elrashdy, Murtaza M Tambuwala, Sk Sarif Hassan, Parise Adadi, Murat Seyran, Tarek Mohamed Abd El-Aziz, Nima Rezaei, Amos Lal, Alaa A A Aljabali, Ramesh Kandimalla and 15 more

Open access · greenAbstract readReview
In one paragraph

Review in Autoimmunity reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. FcFrontiers in cardiovascular medicine · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 16 countries.

Fatma ElrashdyDepartment of Endemic Medicine and Hepatogastroenterology, Kasr Alainy, Cairo University, Cairo, Egypt. Electronic address: Fatmaelrashdy@kasralainy.edu.eg.
Murtaza M TambuwalaSchool of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, United Kingdom. Electronic address: m.tambuwala@ulster.ac.uk.
Sk Sarif HassanDepartment of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 722140 Paschim Medinipur, West Bengal, India.
Parise AdadiDepartment of Food Science, University of Otago, Dunedin, New Zealand.
Murat SeyranDoctoral Student in Natural and Technical Sciences (SPL 44), University of Vienna, Währinger Straße, A-1090 Vienna, Austria. Electronic address: a11851761@unet.univie.ac.at.
Tarek Mohamed Abd El-AzizZoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt; Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. Electronic address: mohamedt1@uthscsa.edu.
Nima RezaeiResearch Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden.
Amos LalDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, USA.
Alaa A A AljabaliDepartment of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Irbid 21163, P. O. BOX 566, Jordan. Electronic address: alaaj@yu.edu.jo.
Ramesh KandimallaApplied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India; Department of Biochemistry, Kakatiya Medical College, Warangal, India.
Nicolas G BazanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, Louisiana, 70112, USA. Electronic address: nbazan@lsuhsc.edu.
Gajendra Kumar AzadDepartment of Zoology, Patna University, Patna, Bihar 800005, India. Electronic address: gkazad@patnauniversity.ac.in.
Samendra P SherchanDepartment of Environmental Health Sciences, Tulane University, New Orleans, LA 70112, USA. Electronic address: sshercha@tulane.edu.
Pabitra Pal ChoudhuryApplied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, West Bengal, India.
Ángel Serrano-ArocaBiomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, Valencia 46001, Spain. Electronic address: angel.serrano@ucv.es.
Kazuo TakayamaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan. Electronic address: kazuo.takayama@cira.kyoto-u.ac.jp.
Gaurav ChauhanSchool of Engineering and Sciences, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, 64849 Monterrey, Nuevo León, Mexico. Electronic address: gchauhan@tec.mx.
Damiano PizzolItalian Agency for Development Cooperation -, Khartoum, Sudan Street 33, Al Amarat, Sudan.
Debmalya BarhInstitute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India; and Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil. Electronic address: dr.barh@gmail.com.
Pritam Kumar PandaCondensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden. Electronic address: pritam.panda@physics.uu.se.
Yogendra K MishraUniversity of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, 6400 Sønderborg, Denmark. Electronic address: mishra@mci.sdu.dk.
Giorgio PalùDepartment of Molecular Medicine, University of Padova, Italy. Electronic address: giorgio.palu@unipd.it.
Kenneth LundstromPanTherapeutics, Lutry, Switzerland.
Elrashdy M RedwanBiological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: lradwan@kau.edu.sa.
Vladimir N UverskyDepartment of Molecular Medicine, University of South Florida, Tampa, FL, United States. Electronic address: vuversky@usf.edu.
Cairo University · EGChildren's Medical Center · IRIndian Institute of Chemical Technology · INIndian Statistical Institute · INInstitute of Bioinformatics and Applied Biotechnology · INKing Abdulaziz University · SAKyoto University · JPLouisiana State University Health Sciences Center New Orleans · USMayo Clinic in Florida · USPatna University · INTecnológico de Monterrey · MXThe University of Texas Health Science Center at San Antonio · USTulane University · USUniversity of Otago · NZUniversity of Padua · ITUniversity of Southern Denmark · DKUniversity of South Florida · USUniversity of Ulster · GBUniversity of Vienna · ATUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.

Indexed as

COVID-19Severe acute respiratory syndrome-related coronavirusViral VaccinesAutoimmunityCOVID-19 VaccinesHumansSARS-CoV-2VaccinationCOVID-19 VaccinesViral VaccinesAdenoviral vector-based vaccineAutoimmune reactionCOVID-19Lipid nanoparticle-mRNA-based vaccineVaccine-induced immune thrombotic thrombocytopenia

Identifiers

PMID34508917
PMCPMC8426137
OpenAlexW3198971950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.