Evidence map›Paper›PMID 34508843›Full record

ArticleInternational journal of pharmaceutics2021

Effect of inflow conditioning for dry powder inhalers.

Gajendra Singh, Albyn Lowe, Athiya Azeem, Shaokoon Cheng, Hak-Kim Chan, Ross Walenga, Agisilaos Kourmatzis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Gajendra SinghSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia.
Albyn LoweSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia.
Athiya AzeemSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia.
Shaokoon ChengSchool of Engineering, Macquarie University, NSW 2109, Australia.
Hak-Kim ChanSchool of Pharmacy, The University of Sydney, NSW 2006, Australia.
Ross WalengaDivision of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Agisilaos KourmatzisSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia. Electronic address: agisilaos.kourmatzis@sydney.edu.au.
The University of Sydney · AUMacquarie University · AUUnited States Food and Drug Administration · US

Funding

Development of computational models to predict delivery of inhalation drug powders: from deagglomeration in devices to deposition in airwaysU01FD006525 · FDA · UNIVERSITY OF SYDNEY · PI CHAN, KIM, CHENG, SHAOKOON · 2018 to 2020
$400k
FDA HHS U01 FD006525
6 · The paper itself

Abstract

The transport of pharmaceutical dry powder inside an optically accessible inhaler-like device is studied using both macro- and microscopic high-speed imaging. The investigation aims to systematically study the effect of inflow modifications on the dispersion characteristics of agglomerates inside a dry powder inhaler (DPI) geometry. An inhaler device was designed with geometrical features akin to commercial inhalers used in the current market and research oriented inhalers such as the Twincer®: two offset inlet channels (one with a powder pocket), a clockwise swirling chamber and a single outlet channel. At the device outlet, a vacuum pump was fitted with an actuator and calibrated to achieve a steady state inhalation with a peak flowrate of 85 and 125 L/min. Airflow conditions at the intake of the device were strategically perturbed in order to induce powder fluidisation and dispersion using turbulence grids and through physically obstructing channel streams in order to achieve changes in flow behaviour (e.g., flow separation). Complete fluidisation of the powder bed was observed with image processing enabling statistics on de-agglomerated fragment size and velocity. A range of behaviour was noted including local turbulence through introduction of a grid, bimodal fragment size behaviour for cohesive mannitol powder, as well as introduction of low velocity zones in the device through flow splitting. The geometry enables simple systematic study of inflow conditions into a DPI-like device with the data being useful for study of a given powder formulation (mannitol) and validation of computational models.

Indexed as

Dry Powder InhalersLungAdministration, InhalationAerosolsEquipment DesignPowdersAerosolsPowdersDry powder inhalerPharmaceutical drugSwirlTurbulence grid

Identifiers

PMID34508843
PMCPMC8720028
OpenAlexW3196331488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.