ArticleNeuro-oncology2022
Recent advances and new discoveries in the pipeline of the treatment of primary spinal tumors and spinal metastases: a scoping review of registered clinical studies from 2000 to 2020.
Article in Neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Robot-assisted technique versus freehand technique for spine surgery: an umbrella review.Annals of medicine · 2025Pooled it
- Prognostic Value of Perioperative Anemia in Neurosurgical-Oncological Treatment of Spinal Metastases.International journal of cancer · 2026Article
- Article
- Outcomes of patients with cervical spine metastasis treated with different surgical approaches-decision based on location.World journal of surgical oncology · 2026Article
- The application of robotic and artificial intelligence technologies in spinal surgery: a review focused on prospects in remote areas of China.Journal of robotic surgery · 2025Review
- Review
- Diagnostic imaging confusion in infectious spondylitis.Journal of orthopaedic surgery and research · 2025Review
- Impact of Personalized Recovery Interventions on Spinal Instability and Psychological Distress in Oncological Patients with Vertebral Metastases.Diseases (Basel, Switzerland) · 2025Article
- Bone mineral density as potential individual prognostic biomarker in patients with neurosurgically treated spinal metastasis.Journal of cancer research and clinical oncology · 2025Article
- Knowledge, Attitude, and Practice Toward Spinal Cord Tumors Among Patients and Their Families in Beijing: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- The disparity in pediatric spinal cord tumor clinical trials: A scoping review of registered clinical trials from 1989 to 2023.Neuro-oncology practice · 2024Article
- Article
- Epidural angioleiomyoma: an extraordinary cause of compressive myelopathy-MRI findings with histopathological correlation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Synchronous versus metachronous spinal metastasis: a comparative study of survival outcomes following neurosurgical treatment.Journal of cancer research and clinical oncology · 2024Article
- The evolution of spinal cord surgery: history, people, instruments, and results.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Diagnostic Approach and Differences between Spinal Infections and Tumors.Diagnostics (Basel, Switzerland) · 2023Review
- An emerging role of inflammasomes in spinal cord injury and spinal cord tumor.Frontiers in immunology · 2023Review
- Risk-adapted stereotactic body radiotherapy for patients with cervical spinal metastases.Cancer science · 2022Article
- Spinal oncologic paraparesis: Analysis of neurological and surgical outcomes in patients with intramedullary, extramedullary, and extradural tumors.Frontiers in oncology · 2022Article
- Postoperative prolonged mechanical ventilation correlates to poor survival in patients with surgically treated spinal metastasis.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of spinal oncology has substantially evolved over the past decades. This review synthesizes and appraises what was learned and what will potentially be discovered from the recently completed and ongoing clinical studies related to the treatment of primary and secondary spinal neoplasms. This scoping review included all clinical studies on the treatment of spinal neoplasms registered in the ClinicalTrials.gov website from February 2000 to December 2020. The terms "spinal cord tumor," "spinal metastasis," and "metastatic spinal cord compression" were used. Of the 174 registered clinical studies on primary spinal tumors and spinal metastasis, most of the clinical studies registered in this American registry were interventional studies led by single institutions in North America (n = 101), Europe (n = 43), Asia (n = 24), or other continents (n = 6). The registered clinical studies mainly focused on treatment strategies for spinal neoplasms (90.2%) that included investigating stereotactic radiosurgery (n = 33), radiotherapy (n = 21), chemotherapy (n = 20), and surgical technique (n = 11). Of the 69 completed studies, the results from 44 studies were published in the literature. In conclusion, this review highlights the key features of the 174 clinical studies on spinal neoplasms that were registered from 2000 to 2020. Clinical trials were heavily skewed toward the metastatic population as opposed to the primary tumors which likely reflects the rarity of the latter condition and associated challenges in undertaking prospective clinical studies in this population. This review serves to emphasize the need for a focused approach to enhancing translational research in spinal neoplasms with a particular emphasis on primary tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.