Evidence map›Paper›PMID 34508399›Full record

ArticleJNMA; journal of the Nepal Medical Association2021

Tofacitinib as an Adjunct Immunomodulator for Treatment of a Patient with Severe COVID-19: A Case Report.

Gentle Sunder Shrestha, Bidesh Bista, Ashesh Dhungana, Nimesh Poudel, Shraddha Bhattarai, Manjit Shrestha, Sandip Bhandari, Binit Vaidya

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JNMA; journal of the Nepal Medical Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Gentle Sunder ShresthaDepartment of Anaesthesiology, Tribhuvan University Teaching Hospital, Kathmandu.
Bidesh BistaDepartment of Internal Medicine, Civil Service Hospital of Nepal, Kathmandu, Nepal.
Ashesh DhunganaDepartment of Internal Medicine, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.
Nimesh PoudelDepartment of Internal Medicine, Kathmandu Medical College and Teaching Hospital, Kathmandu, Nepal.
Shraddha BhattaraiDepartment of Critical Care Medicine, Alka Hospital Pvt. Ltd, Lalitpur, Nepal.
Manjit ShresthaDepartment of Critical Care Medicine, Alka Hospital Pvt. Ltd, Lalitpur, Nepal.
Sandip BhandariDepartment of Anaesthesiology, Shahid Gangalal National Heart Centre, Kathmandu, Nepal.
Binit VaidyaDepartment of Rheumatology, National Center for Rheumatic Diseases, Kathmandu, Nepal.
Civil Service Hospital · NPKathmandu Medical College Teaching Hospital · NPNational Academy of Medical Sciences · NPShahid Gangalal National Heart Centre · NPTribhuvan University Teaching Hospital · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe coronavirus disease 2019 can be associated with progressive respiratory failure. In addition to respiratory support and other supportive care, use of corticosteroids has shown to improve outcome. Despite the use of steroids, a significant proportion of patients progressively worsen. Adjunct immunomodulators have been studied in addition to steroids in these patients. Here we present a successful use of tofacitinib, a Janus Kinase inhibitor, in conjunction with dexamethasone for a patient with rapid worsening of respiratory status and with high level of serum inflammatory biomarkers.

Indexed as

COVID-19HumansImmunologic FactorsPiperidinesPyrimidinesPyrrolesSARS-CoV-2Immunologic FactorsPiperidinesPyrimidinesPyrrolestofacitinib

Identifiers

PMID34508399
PMCPMC8369566
OpenAlexW3180056645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.