Evidence map›Paper›PMID 34508273›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2022

Hippocampal sclerosis and epilepsy surgery in neurofibromatosis type 1: case report of a 3-year-old child explored by SEEG and review of the literature.

Claudine Sculier, Delphine Taussig, Alec Aeby, Jerry Blustajn, Olivier Bekaert, Martine Fohlen

Open access · greenAbstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Claudine SculierDépartement de Neurologie Pédiatrique, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Delphine TaussigNeurophysiologie Et Epileptologie, Université Paris Saclay-APHP, Le Kremlin Bicêtre, France.
Alec AebyDépartement de Neurologie Pédiatrique, Hôpital Des Enfants Reine Fabiola (HUDERF), Université Libre de Bruxelles, Brussels, Belgium.
Jerry BlustajnImagerie Médicale, Hôpital Fondation Rothschild, Paris, France.
Olivier BekaertNeurochirurgie Pédiatrique, Hôpital Fondation Rothschild, 29 rue Manin, 75019, Paris, France.
Martine FohlenNeurochirurgie Pédiatrique, Hôpital Fondation Rothschild, 29 rue Manin, 75019, Paris, France. mfohlen@for.paris.ORCID 0000-0003-1331-9240
Fondation de Rothschild · FRUniversité Libre de Bruxelles · BESorbonne Université · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEpilepsy associated with neurofibromatosis type 1 (NF1) is infrequent and usually controlled with anti-epileptic drugs. However, in some drug-resistant patients a presurgical evaluation should be considered. Hippocampal sclerosis (HS) is one of the rare causes of epilepsy in neurofibromatosis type 1, which can lead to surgery.

methodsWe present a three-year-old child with refractory epilepsy associated with several structural brain abnormalities but normal hippocampi on brain MRI and a heterozygous variant in the NF1 gene (c.2542G > A). A complete presurgical evaluation was performed including stereo-electroencephalography (SEEG).

resultsUsual seizures were recorded, and the seizure onset zone was delineated in the anterior hippocampus. Pathological examination performed after a tailored mesio-temporal resection confirmed hippocampal sclerosis, and the child achieved seizure freedom with 2 years of follow-up.

conclusionThis rare pediatric case illustrates that NF1 may be associated with early-onset refractory epilepsy secondary to MRI-negative HS, supporting the major role of SEEG in the presurgical evaluation of patients with extended cortical malformations.

Indexed as

Drug Resistant EpilepsyEpilepsyNeurodegenerative DiseasesNeurofibromatosis 1ChildChild, PreschoolElectroencephalographyHippocampusHumansMagnetic Resonance ImagingSclerosisSeizuresTreatment OutcomeChildrenDrug-resistant epilepsyInvasive recordingMesio-temporal epilepsy

Identifiers

PMID34508273
OpenAlexW3196720037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.