Evidence map›Paper›PMID 34508124›Full record

ArticleScientific reports2021

AngioNet: a convolutional neural network for vessel segmentation in X-ray angiography.

Kritika Iyer, Cyrus P Najarian, Aya A Fattah, Christopher J Arthurs, S M Reza Soroushmehr, Vijayakumar Subban, Mullasari A Sankardas, Raj R Nadakuditi, Brahmajee K Nallamothu, C Alberto Figueroa

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  5. Medical & biological engineering & computing · 2026
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  19. Optimizing cardiovascular image segmentation through integrated hierarchical features and attention mechanisms.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024
    Article
  20. Patient-specificFrontiers in cardiovascular medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Kritika IyerUniversity of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA.
Cyrus P NajarianUniversity of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA.
Aya A FattahUniversity of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA.
Christopher J ArthursKing's College London, Strand, London, UK.
S M Reza SoroushmehrUniversity of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA.
Vijayakumar SubbanMadras Medical Mission, Chennai, Tamil Nadu, India.
Mullasari A SankardasMadras Medical Mission, Chennai, Tamil Nadu, India.
Raj R NadakuditiUniversity of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA.
Brahmajee K NallamothuUniversity of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA.
C Alberto FigueroaUniversity of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA. figueroc@med.umich.edu.
University of Michigan–Ann Arbor · USMadras Medical Mission · INKing's College London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Coronary Artery Disease (CAD) is commonly diagnosed using X-ray angiography, in which images are taken as radio-opaque dye is flushed through the coronary vessels to visualize the severity of vessel narrowing, or stenosis. Cardiologists typically use visual estimation to approximate the percent diameter reduction of the stenosis, and this directs therapies like stent placement. A fully automatic method to segment the vessels would eliminate potential subjectivity and provide a quantitative and systematic measurement of diameter reduction. Here, we have designed a convolutional neural network, AngioNet, for vessel segmentation in X-ray angiography images. The main innovation in this network is the introduction of an Angiographic Processing Network (APN) which significantly improves segmentation performance on multiple network backbones, with the best performance using Deeplabv3+ (Dice score 0.864, pixel accuracy 0.983, sensitivity 0.918, specificity 0.987). The purpose of the APN is to create an end-to-end pipeline for image pre-processing and segmentation, learning the best possible pre-processing filters to improve segmentation. We have also demonstrated the interchangeability of our network in measuring vessel diameter with Quantitative Coronary Angiography. Our results indicate that AngioNet is a powerful tool for automatic angiographic vessel segmentation that could facilitate systematic anatomical assessment of coronary stenosis in the clinical workflow.

Identifiers

PMID34508124
PMCPMC8433338
OpenAlexW3200595552

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.