Evidence map›Paper›PMID 34508072›Full record

ArticleNature communications2021

Suppressing mosquito populations with precision guided sterile males.

Ming Li, Ting Yang, Michelle Bui, Stephanie Gamez, Tyler Wise, Nikolay P Kandul, Junru Liu, Lenissa Alcantara, Haena Lee, Jyotheeswara R Edula and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Immunogenicity, Safety, and Efficacy of a Tetravalent Dengue Vaccine in Children and Adolescents: An Analysis by Age Group.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  2. Clinical Safety Experience of TAK-003 for Dengue Fever: A New Tetravalent Live Attenuated Vaccine Candidate.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
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  12. Article
  13. Review
  14. Article
  15. Mosquito sex determination: recent advances and applications.Current opinion in insect science · 2025
    Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ming Li *Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7578-4968
Ting Yang *Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-7201-4231
Michelle BuiDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Stephanie GamezDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-0665-0066
Tyler WiseDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Nikolay P KandulDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Junru LiuDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-6198-8150
Lenissa AlcantaraDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Haena LeeDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Jyotheeswara R EdulaDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Robyn RabanDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Yinpeng ZhanDepartment of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
Yijin WangDepartment of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
Nick DeBeaubienDepartment of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
Jieyan ChenDepartment of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
Héctor M Sánchez CDivisions of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.
Jared B BennettDivisions of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.
Igor AntoshechkinDivision of Biology and Biological Engineering (BBE), California Institute of Technology, Pasadena, CA, USA.
Craig MontellDepartment of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.ORCID 0000-0001-5637-1482
John M MarshallDivisions of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.ORCID 0000-0003-0603-7341
Omar S AkbariDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA. oakbari@ucsd.edu.ORCID 0000-0002-6853-9884

Funding

Precision guided SIT for the control of vector-borne diseaseR01AI151004 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKBARI, OMAR SULTAN · 2020 to 2024
$2.3M
Receptors and channels controlling sensation and behavior in Aedes aegyptiR56AI153334 · NIAID · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, CRAIG · 2020 to 2020
$513k
NIAID NIH HHS R01 AI151004NIAID NIH HHS R56 AI153334
6 · The paper itself

Abstract

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic control system termed precision-guided sterile insect technique (pgSIT) in Aedes aegypti. PgSIT uses a simple CRISPR-based approach to generate flightless females and sterile males that are deployable at any life stage. Supported by mathematical models, we empirically demonstrate that released pgSIT males can compete, suppress, and even eliminate mosquito populations. This platform technology could be used in the field, and adapted to many vectors, for controlling wild populations to curtail disease in a safe, confinable, and reversible manner.

Indexed as

AedesAnimalsAnimals, Genetically ModifiedArbovirusesChikungunya FeverDengueFemaleHumansInfertility, MaleMaleModels, BiologicalMosquito ControlMosquito VectorsYellow FeverZika VirusZika Virus Infection

Identifiers

PMID34508072
PMCPMC8433431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.