Evidence map›Paper›PMID 34508071›Full record

ArticleNature communications2021

Functional basis of electron transport within photosynthetic complex I.

Katherine H Richardson, John J Wright, Mantas Šimėnas, Jacqueline Thiemann, Ana M Esteves, Gemma McGuire, William K Myers, John J L Morton, Michael Hippler, Marc M Nowaczyk and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Distinct Valence States of the [4Fe4S] Cluster Revealed in the Hydrogenase CrHydA1.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Electron transfer in biological systems.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Darobactin B Stabilises a Lateral-Closed Conformation of the BAM Complex inAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  14. Article
  15. ROS production and signalling in chloroplasts: cornerstones and evolving concepts.The Plant journal : for cell and molecular biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Katherine H RichardsonSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
John J WrightSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-8987-4449
Mantas ŠimėnasLondon Centre for Nanotechnology, University College London, London, UK.
Jacqueline ThiemannPlant Biochemistry, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.ORCID http://orcid.org/0000-0003-0286-2862
Ana M EstevesSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
Gemma McGuireSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
William K MyersInorganic Chemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5935-9112
John J L MortonLondon Centre for Nanotechnology, University College London, London, UK.ORCID http://orcid.org/0000-0002-0891-1111
Michael HipplerInstitute of Plant Biology and Biotechnology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-9670-6101
Marc M NowaczykPlant Biochemistry, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.ORCID http://orcid.org/0000-0002-9269-0672
Guy T HankeSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK. g.hanke@qmul.ac.uk.ORCID http://orcid.org/0000-0002-6167-926X
Maxie M RoesslerDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, UK. m.roessler@imperial.ac.uk.ORCID http://orcid.org/0000-0002-5291-4328
Queen Mary University of London · GBLondon Centre for Nanotechnology · GBRuhr University Bochum · DEImperial College London · GBOkayama University · JPUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R004838/1
6 · The paper itself

Abstract

Photosynthesis and respiration rely upon a proton gradient to produce ATP. In photosynthesis, the Respiratory Complex I homologue, Photosynthetic Complex I (PS-CI) is proposed to couple ferredoxin oxidation and plastoquinone reduction to proton pumping across thylakoid membranes. However, little is known about the PS-CI molecular mechanism and attempts to understand its function have previously been frustrated by its large size and high lability. Here, we overcome these challenges by pushing the limits in sample size and spectroscopic sensitivity, to determine arguably the most important property of any electron transport enzyme - the reduction potentials of its cofactors, in this case the iron-sulphur clusters of PS-CI (N0, N1 and N2), and unambiguously assign them to the structure using double electron-electron resonance. We have thus determined the bioenergetics of the electron transfer relay and provide insight into the mechanism of PS-CI, laying the foundations for understanding of how this important bioenergetic complex functions.

Indexed as

Energy MetabolismBacterial ProteinsElectron Spin Resonance SpectroscopyElectron TransportIron-Sulfur ProteinsPhotosystem I Protein ComplexSynechocystisBacterial ProteinsIron-Sulfur ProteinsPhotosystem I Protein Complex

Identifiers

PMID34508071
PMCPMC8433477
OpenAlexW3196571747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.