Evidence map›Paper›PMID 34507987›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Actin filament debranching regulates cell polarity during cell migration and asymmetric cell division.

Chao Xie, Yuxiang Jiang, Zhiwen Zhu, Shanjin Huang, Wei Li, Guangshuo Ou

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

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  8. The role of actin cytoskeleton component Arp2/3 in inflammatory response.Frontiers in cell and developmental biology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Mechanisms of actin disassembly and turnover.The Journal of cell biology · 2023
    Review
  18. Nuclear Actin Polymerization Regulates Cell Epithelial-Mesenchymal Transition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chao XieTsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences and Ministry of Education Key Laboratory for Protein Science, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-1140-2254
Yuxiang JiangSchool of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-1369-8818
Zhiwen ZhuTsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences and Ministry of Education Key Laboratory for Protein Science, Tsinghua University, Beijing 100084, China.
Shanjin HuangSchool of Life Sciences, Tsinghua University, Beijing 100084, China.
Wei LiSchool of Medicine, Tsinghua University, Beijing 100084, China weili_med@mail.tsinghua.edu.cn guangshuoou@tsinghua.edu.cn.ORCID 0000-0001-9133-461X
Guangshuo OuTsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences and Ministry of Education Key Laboratory for Protein Science, Tsinghua University, Beijing 100084, China; weili_med@mail.tsinghua.edu.cn guangshuoou@tsinghua.edu.cn.ORCID 0000-0003-1512-7824
Center for Life Sciences · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of the branched actin networks is essential for cell polarity, but it remains unclear how the debranching activity of actin filaments contributes to this process. Here, we showed that an evolutionarily conserved coronin family protein, the

Indexed as

Actin CytoskeletonActin-Related Protein 2-3 ComplexActinsAnimalsAsymmetric Cell DivisionCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MovementCell PolarityMicrofilament ProteinsNeural Stem CellsActin-Related Protein 2-3 ComplexActinsCaenorhabditis elegans Proteinscoronin proteinsMicrofilament ProteinsPOD-1 protein, C elegansactin debranchingcell polaritycoronindirectional cell migration

Identifiers

PMID34507987
PMCPMC8449360
OpenAlexW3196880432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.