Evidence map›Paper›PMID 34507985›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

CREBA and CREBB in two identified neurons gate long-term memory formation in

Hsuan-Wen Lin, Chun-Chao Chen, J Steven de Belle, Tim Tully, Ann-Shyn Chiang

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Redox regulation of memory formation by Rrp1 inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Use-Dependent, Untapped Dual Kinase Signaling Localized in Brain Learning Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Long-term neuropeptide modulation of female sexual drive via the TRP channel inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Multi-faceted regulation of CREB family transcription factors.Frontiers in molecular neuroscience · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Circadian disruption of memory consolidation inFrontiers in systems neuroscience · 2023
    Article
  17. CREBB repression of protein synthesis in mushroom body gates long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hsuan-Wen LinBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
Chun-Chao ChenBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
J Steven de BelleBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID 0000-0001-6378-3944
Tim TullyBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan; ttully@gapp.nthu.edu.tw aschiang@life.nthu.edu.tw.
Ann-Shyn ChiangBrain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan; ttully@gapp.nthu.edu.tw aschiang@life.nthu.edu.tw.ORCID 0000-0001-9668-7115
National Tsing Hua University · TWKaohsiung Medical University · TWUniversity of Nevada, Las Vegas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Episodic events are frequently consolidated into labile memory but are not necessarily transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM formation are poorly understood, however, especially at the resolution of identified neurons. Here, we demonstrate enhanced LTM following aversive olfactory conditioning in

Indexed as

AnimalsConditioning, ClassicalConditioning, PsychologicalCyclic AMP Response Element-Binding ProteinCyclic AMP Response Element-Binding Protein ADrosophila melanogasterDrosophila ProteinsFemaleGene ExpressionGene Expression RegulationMaleMemory, Long-TermNeuronsOlfactory PerceptionSmellTrans-ActivatorsCrebA protein, DrosophilaCrebB protein, DrosophilaCyclic AMP Response Element-Binding ProteinCyclic AMP Response Element-Binding Protein ADrosophila ProteinsTrans-ActivatorsCREBACREBBgene regulationmemory consolidationsingle neurons

Identifiers

PMID34507985
PMCPMC8449312
OpenAlexW3196601740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.