Evidence map›Paper›PMID 34507966›Full record

ArticleOccupational and environmental medicine2021

Temporal association of prostate cancer incidence with World Trade Center rescue/recovery work.

David G Goldfarb, Rachel Zeig-Owens, Dana Kristjansson, Jiehui Li, Robert M Brackbill, Mark R Farfel, James E Cone, Janette Yung, Amy R Kahn, Baozhen Qiao and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Occupational and environmental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Characteristics of Cancers in Community Members Exposed to the World Trade Center Disaster at a Young Age.International journal of environmental research and public health · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

David G GoldfarbDepartment of Medicine, Division of Pulmonary Medicine, Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0003-2682-7543
Rachel Zeig-OwensDepartment of Medicine, Division of Pulmonary Medicine, Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0002-8679-2306
Dana KristjanssonDepartment of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-0687-2910
Jiehui LiWorld Trade Center Health Registry, New York City Department of Health and Mental Hygiene, New York, New York, USA.ORCID 0000-0002-7812-8878
Robert M BrackbillWorld Trade Center Health Registry, New York City Department of Health and Mental Hygiene, New York, New York, USA.ORCID 0000-0003-0518-0330
Mark R FarfelWorld Trade Center Health Registry, New York City Department of Health and Mental Hygiene, New York, New York, USA.ORCID 0000-0002-9952-9937
James E ConeWorld Trade Center Health Registry, New York City Department of Health and Mental Hygiene, New York, New York, USA.ORCID 0000-0003-2145-1348
Janette YungWorld Trade Center Health Registry, New York City Department of Health and Mental Hygiene, New York, New York, USA.ORCID 0000-0002-0144-1292
Amy R KahnBureau of Cancer Epidemiology, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-1025-6312
Baozhen QiaoBureau of Cancer Epidemiology, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-8407-7835
Maria J SchymuraBureau of Cancer Epidemiology, New York State Department of Health, Albany, New York, USA.ORCID 0000-0003-0587-8667
Mayris P WebberBureau of Health Services, World Trade Center Health Program, Fire Department of the City of New York, Brooklyn, New York, USA.ORCID 0000-0002-8322-4573
Christopher R DasaroDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-9924-195X
Moshe ShapiroDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-9081-9743
Andrew C ToddDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-7864-009X
David J PrezantDepartment of Medicine, Division of Pulmonary Medicine, Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0001-9562-0330
Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0002-3811-2791
Charles B HallDepartment of Epidemiology & Population Health, Division of Biostatistics, Albert Einstein College of Medicine, Bronx, New York, USA charles.hall@einsteinmed.org.ORCID 0000-0001-9982-8120
New York City Department of Health and Mental Hygiene · USAlbert Einstein College of Medicine · USIcahn School of Medicine at Mount Sinai · USNew York State Department of Health · USMedica (Italy) · ITNew York City Fire Department · USNorwegian Institute of Public Health · NO

Funding

Extension of the World Trade Center RegistryU50OH009739 · OH · NEW YORK CITY HEALTH/MENTAL HYGIENE · PI FARFEL, MARK R · 2009 to 2025
$120.0M
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
WORLD TRADE CENTER REGISTRYU50TS272750 · TS · NEW YORK CITY HEALTH/MENTAL HYGIENE · PI FARFEL, MARK R · 2005 to 2008
$12.3M
Mortality among WTC rescue and recovery workersU01OH011480 · OH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOFFETTA, PAOLO, HALL, CHARLES B · 2017 to 2020
$2.4M
Incidence, Latency, and Survival of Cancer Following World Trade Center ExposureU01OH011315 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BOFFETTA, PAOLO, HALL, CHARLES B · 2016 to 2018
$1.4M
Incidence, Latency, and Survival of Cancer Following World Trade Center ExposureU01OH011932 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HALL, CHARLES B · 2019 to 2019
$1.1M
Detection and Incidence of Thyroid Cancer among Three Cohorts of WTC-Exposed Rescue and Recovery WorkersU01OH011931 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ZEIG-OWENS, RACHEL · 2019 to 2019
$555k
Detection and Incidence of Thyroid Cancer among Three Cohorts of WTC-Exposed Rescue and Recovery WorkersU01OH011681 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ZEIG-OWENS, RACHEL · 2018 to 2018
$350k
ACL HHS U01OH011315ACL HHS U50OH009739ATSDR CDC HHS U50 TS272750NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P30 CA013330NIOSH CDC HHS U01 OH011315NIOSH CDC HHS U01 OH011480NIOSH CDC HHS U01 OH011681NIOSH CDC HHS U01 OH011931NIOSH CDC HHS U01 OH011932NIOSH CDC HHS U50 OH009739
6 · The paper itself

Abstract

backgroundThe World Trade Center (WTC) attacks on 11 September 2001 created a hazardous environment with known and suspected carcinogens. Previous studies have identified an increased risk of prostate cancer in responder cohorts compared with the general male population.

objectivesTo estimate the length of time to prostate cancer among WTC rescue/recovery workers by determining specific time periods during which the risk was significantly elevated.

methodsPerson-time accruals began 6 months after enrolment into a WTC cohort and ended at death or 12/31/2015. Cancer data were obtained through linkages with 13 state cancer registries. New York State was the comparison population. We used Poisson regression to estimate hazard ratios and 95% CIs; change points in rate ratios were estimated using profile likelihood.

resultsThe analytic cohort included 54 394 male rescue/recovery workers. We observed 1120 incident prostate cancer cases. During 2002-2006, no association with WTC exposure was detected. Beginning in 2007, a 24% increased risk (HR: 1.24, 95% CI 1.16 to 1.32) was observed among WTC rescue/recovery workers when compared with New York State. Comparing those who arrived earliest at the disaster site on the morning of 11 September 2001 or any time on 12 September 2001 to those who first arrived later, we observed a positive, monotonic, dose-response association in the early (2002-2006) and late (2007-2015) periods.

conclusionsRisk of prostate cancer was significantly elevated beginning in 2007 in the WTC combined rescue/recovery cohort. While unique exposures at the disaster site might have contributed to the observed effect, screening practices including routine prostate specific antigen screening cannot be discounted.

Indexed as

Emergency RespondersSeptember 11 Terrorist AttacksAdultHumansIncidenceMaleModels, StatisticalNew York CityOccupational ExposureProstatic NeoplasmsRisk FactorsTime FactorsYoung Adultenvironmental exposureexposures or occupational groupslongitudinal studiesmaterialsmedical oncologyrisk assessment

Identifiers

PMID34507966
PMCPMC8458078
OpenAlexW3197086149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.