ArticleBritish journal of anaesthesia2021
Effect of positive end-expiratory pressure on lung injury and haemodynamics during experimental acute respiratory distress syndrome treated with extracorporeal membrane oxygenation and near-apnoeic ventilation.
Article in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Short-Term Physiological Effects of Moderate PEEP Levels in Invasively Ventilated Patients Without Acute or Chronic Lung Disease.Medical sciences (Basel, Switzerland) · 2026Article
- Association Between Positive End-Expiratory Pressure at Venovenous Extracorporeal Membrane Oxygenation Initiation and Liberation Outcomes in Acute Respiratory Distress Syndrome: A Multicenter Retrospective Study.Critical care explorations · 2026Article
- A systematic review of adult animal models investigating ECMO use for ARDS: where to from here.Intensive care medicine experimental · 2025Review
- Positive end-expiratory pressure management in patients with severe ARDS: implications of prone positioning and extracorporeal membrane oxygenation.Critical care (London, England) · 2024Review
- Acute Lung Injury in aortic dissection : new insights in anesthetic management strategies.Journal of cardiothoracic surgery · 2023Review
- Effects of airway pressure release ventilation on multi-organ injuries in severe acute respiratory distress syndrome pig models.BMC pulmonary medicine · 2022Article
- A clinically relevant model of acute respiratory distress syndrome in human-size swine.Disease models & mechanisms · 2022Article
- Distribution and Magnitude of Regional Volumetric Lung Strain and Its Modification by PEEP in Healthy Anesthetized and Mechanically Ventilated Dogs.Frontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung rest has been recommended during extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS). Whether positive end-expiratory pressure (PEEP) confers lung protection during ECMO for severe ARDS is unclear. We compared the effects of three different PEEP levels whilst applying near-apnoeic ventilation in a model of severe ARDS treated with ECMO.
methodsAcute respiratory distress syndrome was induced in anaesthetised adult male pigs by repeated saline lavage and injurious ventilation for 1.5 h. After ECMO was commenced, the pigs received standardised near-apnoeic ventilation for 24 h to maintain similar driving pressures and were randomly assigned to PEEP of 0, 10, or 20 cm H
resultsAll pigs developed severe ARDS. Oxygenation on ECMO improved with PEEP of 10 or 20 cm H
conclusionsDuring near-apnoeic ventilation and ECMO in experimental severe ARDS, 10 cm H
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