ArticleBMC infectious diseases2021
Cardiac evaluation in adults with dengue virus infection by serial echocardiography.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers.PLoS neglected tropical diseases · 2026Pooled it
- Pooled it
- [Clinical characteristics and outcomes of neonatal dengue fever in Foshan].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Integrating structured point-of-care ultrasound into dengue fever management: A mini review and comprehensive clinical guide.World journal of critical care medicine · 2026Review
- Serial bedside echocardiography identifies children at risk of recurrent Dengue shock: a prospective cohort study.BMC emergency medicine · 2026Article
- Case Report: Expanded dengue syndrome with acute pancreatitis and pericardial effusion in octogenarians, from recovery to fatal shock.Frontiers in medicine · 2026Article
- Fulminant myocarditis associated with severe dengue in a young patient from the Peruvian Amazon: case report and literature review.Revista peruana de medicina experimental y salud publica · 2025Review
- Cardiovascular complications in acute dengue infection: a population-based cohort study.The Lancet regional health. Western Pacific · 2025Article
- Article
- Evaluation of remote radiologist-interpreted point-of-care ultrasound for suspected dengue patients in a primary health care facility in Colombia.Infectious diseases of poverty · 2023Article
- Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury.Memorias do Instituto Oswaldo Cruz · 2023Article
- Clinical and prognostic relevance of sST2 in adults with dengue-associated cardiac impairment and severe dengue.PLoS neglected tropical diseases · 2022Article
- Electrocardiographic and echocardiographic findings in children with dengue infection.Journal of family medicine and primary care · 2022Article
- Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDengue virus infection (DVI) is a major health problem in many parts of the world. Its manifestations range from asymptomatic infections to severe disease. Although cardiac involvement has been reported in DVI, its incidence has not yet been well established.
methodsFrom July 2016 to January 2018, patients hospitalized at the Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Thailand, with dengue virus infection confirmed by positive NS1 or positive dengue immunoglobulin M findings, participated in the study. We characterized the incidence and change in cardiac function by serial echocardiography and levels of troponin-T and creatine kinase-myocardial band (CK-MB) on the day of admission, the day of defervescence, the first day of hypotension (if any), and at 2 week follow-up.
resultsOf the 81 patients evaluated, 6 (7.41%) exhibited elevated biomarker levels. There was no difference in clinical presentation amongst dengue fever, dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), except for the amount of bleeding. Cardiac involvement was found in 22.2% of patients: 3 (3.70%) had left ventricular systolic dysfunction, 3 (3.70%) had transient diastolic dysfunction, 6 (7.41%) had increased levels of at least one cardiac biomarker (troponin-T or CK-MB), and 6 (7.41%) had small pericardial effusion. Myocarditis was suspected in only two patients (with DHF); thus, myocarditis was uncommon in patients with dengue virus infection. Three patients developed DSS during admission and were transferred to the intensive care unit.
conclusionCardiac involvement in adults with dengue infection was common, ranging from elevated cardiac biomarker to myocarditis. Abnormalities in cardiac function had resolved spontaneously by the day of follow-up, without specific treatment. We found that DHF was a significant risk factor for cardiac involvement. Echocardiography is the investigation of choice for evaluating the haemodynamic status of patients with DVI, especially in severe dengue.
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