Evidence map›Paper›PMID 34507535›Full record

ArticleBMC infectious diseases2021

Detection and treatment of cerebral toxoplasmosis in an aplastic pediatric post-allogeneic hematopoietic cell transplant patient: a case report.

Danielle Brewer, Margaret L MacMillan, Mark R Schleiss, Satja Issaranggoon Na Ayuthaya, Jo-Anne Young, Christen L Ebens

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Danielle BrewerMedical School, University of Minnesota, Minneapolis, MN, USA.
Margaret L MacMillanDepartment of Pediatrics, Division of Blood and Marrow Transplantation and Cellular Therapy, University of Minnesota, Minneapolis, MN, USA.
Mark R SchleissDepartment of Pediatrics, Division of Infectious Diseases, University of Minnesota, Minneapolis, MN, USA.
Satja Issaranggoon Na AyuthayaDepartment of Pediatrics, Division of Infectious Diseases, University of Minnesota, Minneapolis, MN, USA.
Jo-Anne YoungDepartment of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN, USA.
Christen L EbensDepartment of Pediatrics, Division of Blood and Marrow Transplantation and Cellular Therapy, University of Minnesota, Minneapolis, MN, USA. ebens012@umn.edu.ORCID http://orcid.org/0000-0003-2430-911X
University of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

Institutional Career Development CoreKL2TR002492 · NCATS · UNIVERSITY OF MINNESOTA · PI INGBAR, DAVID H · 2018 to 2022
$6.3M
NCATS NIH HHS KL2 TR002492NCATS NIH HHS KL2TR002492
6 · The paper itself

Abstract

backgroundCerebral toxoplasmosis infection presents with non-specific neurologic symptoms in immunocompromised patients. With lack of measurable adaptive immune responses and reluctance to sample affected brain tissue, expedient diagnosis to guide directed treatment is often delayed. CASE PRESENTATION: We describe the use of cerebrospinal fluid polymerase chain reaction and plasma cell-free DNA technologies to supplement neuroimaging in the diagnosis of cerebral toxoplasmosis in an immunocompromised pediatric patient following allogeneic hematopoietic cell transplantation for idiopathic severe aplastic anemia. Successful cerebral toxoplasmosis treatment included antibiotic therapy for 1 year following restoration of cellular immunity with an allogeneic stem cell boost.

conclusionsPlasma cell-free DNA technology provides a non-invasive method of rapid diagnosis, improving the likelihood of survival from often lethal opportunistic infection in a high risk, immunocompromised patient population.

Indexed as

Anemia, AplasticHematopoietic Stem Cell TransplantationOpportunistic InfectionsToxoplasmosis, CerebralChildHumansTransplantation, HomologousAllogeneic hematopoietic cell transplantationCase reportCell-free DNAImmune mediated cytopeniaSevere aplastic anemiaToxoplasmosis

Identifiers

PMID34507535
PMCPMC8434744
OpenAlexW3198563843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.