Evidence map›Paper›PMID 34506825›Full record

ArticleInternational journal of cardiology2021

Cancer and cardiovascular disease: The impact of cardiac rehabilitation and cardiorespiratory fitness on survival.

Tamara Williamson, Chelsea Moran, Daniele Chirico, Ross Arena, Cemal Ozemek, Sandeep Aggarwal, Tavis Campbell, Deepika Laddu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Tamara WilliamsonDepartment of Psychology, University of Calgary, Calgary, AB, Canada.
Chelsea MoranDepartment of Psychology, University of Calgary, Calgary, AB, Canada.
Daniele ChiricoTotalCardiology™ Rehabilitation, Calgary, AB, Canada; TotalCardiology Research Network, Calgary, AB, Canada; Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
Ross ArenaFaculty of Kinesiology, University of Calgary, Calgary, AB, Canada; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA.
Cemal OzemekDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA.
Sandeep AggarwalTotalCardiology™ Rehabilitation, Calgary, AB, Canada; TotalCardiology Research Network, Calgary, AB, Canada; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA.
Tavis CampbellDepartment of Psychology, University of Calgary, Calgary, AB, Canada; TotalCardiology Research Network, Calgary, AB, Canada; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA; Libin Cardiovascular Institute, University of Calgary, Calgary, Canada.
Deepika LadduTotalCardiology Research Network, Calgary, AB, Canada; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA. Electronic address: dladdu@uic.edu.
University of Calgary · CAHealth Net · USTotal (Canada) · CAUniversity of Illinois Chicago · US

Funding

The impact of a resistance training intervention on blood pressure control in older adults with SarcopeniaK01HL148503 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADDU, DEEPIKA · 2019 to 2023
$901k
NHLBI NIH HHS K01 HL148503
6 · The paper itself

Abstract

backgroundCancer survivors are at increased risk for cardiovascular disease (CVD)-related morbidity and mortality. Exercise-based cardiac rehabilitation (CR) programs improve CVD risk factors, including cardiorespiratory fitness (CRF). The purpose of this study was to investigate: (1) the association between CR completion and survival, and (2) whether CRF improvements translate to increased survival among patients with comorbid cancer and CVD.

methodsPatients with CVD and pre-existing cancer (any type) were referred to a 12-week exercise-based CR program between 01/1996 and 03/2016. Peak metabolic equivalents (METs) were assessed by graded exercise test pre-CR and at 12-weeks. Kaplan-Meier survival and multivariate cox regressions were performed to evaluate impact of CR completion and clinically-meaningful CRF improvements [ΔMETs≥1] on survival, adjusting for relevant covariates.

resultsAmong 442 patients with CVD and cancer referred to CR (67 ± 10 years; 22% women), 361 (82%) completed CR. 102 deaths were recorded during the 12-year observation period. Compared to patients who did not complete CR, patients with comorbid cancer who completed CR demonstrated a survival advantage (63% vs 80.1%, p < .001). CRF improved among completers during the 12-week program (mean change = 0.87 ± 0.93 METs, p < .001); 41% experienced a clinically-meaningful ΔMETs≥1. A survival advantage was not observed in completers who experienced a ΔMETs≥1 improvement (p = .254).

conclusionCompleting a 12-week exercise-based CR program improved CRF and increased survival in patients with CVD and comorbid cancer. The results highlight the survival benefits of completing a CR program among CVD patients who experience added barriers imposed by cancer treatment and survival.

Indexed as

Cardiac RehabilitationCardiorespiratory FitnessCardiovascular DiseasesNeoplasmsExercise TestExercise TherapyFemaleHumansMalecancerCardiac rehabilitationCardio-oncologyCardiorespiratory fitnessCardiovascular diseaseExercise capacitySurvival

Identifiers

PMID34506825
PMCPMC9178663
OpenAlexW3198425742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.