Evidence map›Paper›PMID 34506774›Full record

ArticleBiophysical journal2021

Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca

Yousra El Ghaleb, Monica L Fernández-Quintero, Stefania Monteleone, Petronel Tuluc, Marta Campiglio, Klaus R Liedl, Bernhard E Flucher

Open access · hybridAbstract read
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Identification of novel functional sites in the CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Pathogenic CaCommunications biology · 2026
    Article
  3. Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2025
    Review
  4. Article
  5. Voltage sensors.Molecular pharmacology · 2025
    Review
  6. CaNature communications · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yousra El GhalebDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University Innsbruck, Innsbruck, Austria.
Monica L Fernández-QuinteroDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University Innsbruck, Innsbruck, Austria; Department of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck.
Stefania MonteleoneDepartment of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck; Evotec (UK) Ltd., Abingdon, Oxfordshire, United Kingdom.
Petronel TulucDepartment of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.
Marta CampiglioDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University Innsbruck, Innsbruck, Austria.
Klaus R LiedlDepartment of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck.
Bernhard E FlucherDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University Innsbruck, Innsbruck, Austria. Electronic address: bernhard.e.flucher@i-med.ac.at.
Innsbruck Medical University · ATEvotec (United Kingdom) · GBUniversität Innsbruck · AT

Funding

Austrian Science Fund FWF DOC 30Austrian Science Fund FWF P 30402
6 · The paper itself

Abstract

The voltage-gated calcium channel Ca

Indexed as

Calcium Channels, L-TypeIon Channel GatingCationsPatch-Clamp TechniquesCalcium Channels, L-TypeCations

Identifiers

PMID34506774
PMCPMC8553663
OpenAlexW3197400812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.