Evidence map›Paper›PMID 34506735›Full record

ArticleThe Lancet. Infectious diseases2021

Hospitalisation among vaccine breakthrough COVID-19 infections.

Prerak V Juthani, Akash Gupta, Kelly A Borges, Christina C Price, Alfred I Lee, Christine H Won, Hyung J Chun

Erratum issued 2 registry-linked trialsAbstract readComment
In one paragraph

Article in The Lancet. Infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 94 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05205746 phase2completednot on this map

Phase II Study to Evaluate Immunogenicity and Safety in Subjects With Evidence of Prior Immunity to SARS-CoV-2 of a Single Intramuscular or Intranasal Dose of the Live Recombinant Newcastle Disease Virus Based AVX/COVID-12 Vaccine

TypeinterventionalSponsorLaboratorio Avi-Mex, S.A. de C.V.Ran2021 to 2023Enrolled158ConditionsSARS CoV 2 InfectionArmsRecombinant NDV Vectored Vaccine for SARS-CoV-2, Placebo
NCT05710783 phase2 / phase3completednot on this mapstarted 2022, after this paper: background citation

Phase II/III Parallel, Double-blind, Non-inferiority Study With Active Control, to Evaluate the Immunogenicity and Safety of a Booster Immunization Scheme With a Single Intramuscular Dose of the Recombinant Vaccine Against SARS-CoV-2

TypeinterventionalSponsorLaboratorio Avi-Mex, S.A. de C.V.Ran2022 to 2023Enrolled4,065ConditionsSARS-CoV-2 InfectionArmsAVX-COVID/12, ChAdOx-1-S[recombinant]
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Nirmatrelvir combined with ritonavir for preventing and treating COVID-19.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Nirmatrelvir combined with ritonavir for preventing and treating COVID-19.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. SARS-CoV-2 Vaccines and Multiple Sclerosis: An Update.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Protective effect of vaccination on the risk of cardiovascular disease after SARS-CoV-2 infection.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Prerak V JuthaniDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06511, USA.
Akash GuptaDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06511, USA.
Kelly A BorgesYale Center for Clinical Investigation, Yale School of Medicine, New Haven, CT 06511, USA.
Christina C PriceSection of Immunology, Yale School of Medicine, New Haven, CT 06511, USA.
Alfred I LeeSection of Haematology, Yale School of Medicine, New Haven, CT 06511, USA.
Christine H WonSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT 06511, USA.
Hyung J ChunYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: hyung.chun@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19VaccinesBreakthrough InfectionsCOVID-19 VaccinesHospitalizationHumansSARS-CoV-2COVID-19 VaccinesVaccines

Identifiers

PMID34506735
PMCPMC8423430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.