Evidence map›Paper›PMID 34506714›Full record

ArticleACS chemical biology2021

Protected

Ashley R Brown, Kimberly A Wodzanowski, Cintia C Santiago, Stephen N Hyland, Julianna L Follmar, PapaNii Asare-Okai, Catherine Leimkuhler Grimes

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Bacterial peptidoglycan as a living polymer.Current opinion in chemical biology · 2025
    Review
  5. Evaluation and Comparison ofBiochemistry · 2025
    Article
  6. Chemical biology tools to probe bacterial glycans.Current opinion in chemical biology · 2024
    Review
  7. Article
  8. Minimalist TetrazineJournal of the American Chemical Society · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ashley R BrownDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Kimberly A WodzanowskiDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Cintia C SantiagoDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Stephen N HylandDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Julianna L FollmarDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
PapaNii Asare-OkaiDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Catherine Leimkuhler GrimesDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-0586-2879
University of Delaware · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI POLENOVA, TATYANA · 2014 to 2018
$5.8M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Metabolic carbohydrate cell wall probes for bacterial structure and immune recognition studiesU01CA221230 · NCI · UNIVERSITY OF DELAWARE · PI GRIMES, CATHERINE LEIMKUHLER · 2017 to 2019
$1.1M
NCI NIH HHS U01 CA221230NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758NIGMS NIH HHS T32 GM133395
6 · The paper itself

Abstract

Metabolic glycan probes have emerged as an excellent tool to investigate vital questions in biology. Recently, methodology to incorporate metabolic bacterial glycan probes into the cell wall of a variety of bacterial species has been developed. In order to improve this method, a scalable synthesis of the peptidoglycan precursors is developed here, allowing for access to essential peptidoglycan immunological fragments and cell wall building blocks. The question was asked if masking polar groups of the glycan probe would increase overall incorporation, a common strategy exploited in mammalian glycobiology. Here, we show, through cellular assays, that

Indexed as

Cell WallEscherichia coliMolecular ProbesMuramic AcidsPeptidoglycanPolysaccharidesMolecular ProbesMuramic AcidsN-acetylmuramic acidPeptidoglycanPolysaccharides

Identifiers

PMID34506714
PMCPMC8722712
OpenAlexW3196856226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.