Evidence map›Paper›PMID 34506664›Full record

ArticleChembiochem : a European journal of chemical biology2021

Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity.

Su Yang, Yan Chang, Shan Hazoor, Chad Brautigam, Frank W Foss, Zui Pan, He Dong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Su YangDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
Yan ChangCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.
Shan HazoorDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
Chad BrautigamDepartment of Biophysics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Frank W FossDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
Zui PanCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.
He DongDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
The University of Texas at Arlington · USThe University of Texas Southwestern Medical Center · US

Funding

Oncogenic Function of Ca2+ Channel Orai1 in Esophageal CarcinogenesisR01CA185055 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG, PAN, ZUI · 2015 to 2019
$1.6M
An Inverted Nikon A1R Laser Scanning Confocal MicroscopeS10OD025230 · OD · UNIVERSITY OF TEXAS ARLINGTON · PI PAN, ZUI · 2019 to 2019
$449k
national science foundation 1824614National Science Foundation CHE-0840509National Science Foundation DMR1824614NCI NIH HHS R01 CA185055NIH HHS R01 CA185055NIH HHS S10 OD025230University of Texas at ArlingtonWelch Foundation Y-2031
6 · The paper itself

Abstract

The rational design of materials with cell-selective membrane activity is an effective strategy for the development of targeted molecular imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme-mediated molecular transformation followed by supramolecular assembly to form nanofibers in which cationic clusters are presented on a rigid β-sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self-assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramolecular nanomaterials with emerging membrane activity for a range of disease targeted molecular imaging and therapy applications.

Indexed as

Cell MembraneHeLa CellsHumansIonsMacromolecular SubstancesMolecular StructureParticle SizePeptidesIonsMacromolecular SubstancesPeptidescell selectivitydrug deliverymembrane activitymolecular imagingself-assembly

Identifiers

PMID34506664
PMCPMC11261884
OpenAlexW3197047015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.