Evidence map›Paper›PMID 34506555›Full record

ArticlePloS one2021

Social, economic, and health effects of the COVID-19 pandemic on adolescents retained in or recently disengaged from HIV care in Kenya.

Leslie A Enane, Edith Apondi, Josephine Aluoch, Giorgos Bakoyannis, Jayne Lewis Kulzer, Zachary Kwena, Rami Kantor, Ashley Chory, Adrian Gardner, Michael Scanlon and 4 more

Abstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  20. Substantial Increase in Transactional Sex and HIV Risk Among Adolescents During the COVID-19 Pandemic: Results From a Repeated Cross-Sectional Study in Botswana.AIDS education and prevention : official publication of the International Society for AIDS Education · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Leslie A EnaneDepartment of Pediatrics, The Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.ORCID 0000-0001-8390-5881
Edith ApondiAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Josephine AluochAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Giorgos BakoyannisDepartment of Biostatistics and Health Data Science, Indiana University, Indianapolis, Indiana, United States of America.
Jayne Lewis KulzerDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America.
Zachary KwenaResearch, Care and Treatment Programme, Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Rami KantorDivision of Infectious Diseases, Department of Medicine, Brown University Apert Medical School, Providence, Rhode Island, United States of America.
Ashley ChoryDepartment of Health System Design and Global Health, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Adrian GardnerIndiana University Center for Global Health, Indianapolis, Indiana, United States of America.
Michael ScanlonIndiana University Center for Global Health, Indianapolis, Indiana, United States of America.
Suzanne GoodrichDivision of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.
Kara Wools-KaloustianIndiana University Center for Global Health, Indianapolis, Indiana, United States of America.ORCID 0000-0002-3277-4452
Batya ElulDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
Rachel C VreemanDepartment of Health System Design and Global Health, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Leslie Anne Enane, AGGREY SEMWENDERO SEMEERE · 2006 to 2026
$57.7M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
HIV Drug Resistance, Monitoring and TransmissionK24AI134359 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2018 to 2026
$1.3M
Developing an Instrument to Assess Adolescent Risk for Disengagement from HIV CareK23HD095778 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI ENANE, LESLIE ANNE · 2018 to 2022
$786k
NIAID NIH HHS K24 AI134359NIAID NIH HHS P30 AI042853NIAID NIH HHS U01 AI069911NICHD NIH HHS K23 HD095778NICHD NIH HHS L40 HD103261
6 · The paper itself

Abstract

introductionAdolescents living with HIV (ALHIV, ages 10-19) experience complex challenges to adhere to antiretroviral therapy (ART) and remain in care, and may be vulnerable to wide-scale disruptions during the COVID-19 pandemic. We assessed for a range of effects of the pandemic on ALHIV in western Kenya, and whether effects were greater for ALHIV with recent histories of being lost to program (LTP).

methodsALHIV were recruited from an ongoing prospective study at 3 sites in western Kenya. The parent study enrolled participants from February 2019-September 2020, into groups of ALHIV either 1) retained in care or 2) LTP and traced in the community. Phone interviews from July 2020-January 2021 assessed effects of the pandemic on financial and food security, healthcare access and behaviors, and mental health. Responses were compared among the parent study groups.

resultsPhone surveys were completed with 334 ALHIV or their caregivers, including 275/308 (89.3%) in the retained group and 59/70 (84.3%) among those LTP at initial enrollment. During the pandemic, a greater proportion of LTP adolescents were no longer engaged in school (45.8% vs. 36.4%, p = 0.017). Over a third (120, 35.9%) of adolescents reported lost income for someone they relied on. In total, 135 (40.4%) did not have enough food either some (121, 36.2%) or most (14, 4.2%) of the time. More LTP adolescents (4/59, 6.8% vs. 2/275, 0.7%, p = 0.010) reported increased difficulties refilling ART. Adolescent PHQ-2 and GAD-2 scores were ≥3 for 5.6% and 5.2%, respectively.

conclusionsThe COVID-19 pandemic has had devastating socioeconomic effects for Kenyan ALHIV and their households. ALHIV with recent care disengagement may be especially vulnerable. Meanwhile, sustained ART access and adherence potentially signal resilience and strengths of ALHIV and their care programs. Findings from this survey indicate the critical need for support to ALHIV during this crisis.

Indexed as

Health Services AccessibilityHIV InfectionsPandemicsPatient ComplianceAdolescentChildCOVID-19FemaleHumansKenyaMaleProspective StudiesSurveys and QuestionnairesYoung Adult

Identifiers

PMID34506555
PMCPMC8432853

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.