Evidence map›Paper›PMID 34506303›Full record

ArticleAging2021

Development and validation of a clinical model (DREAM-LDL) for post-stroke cognitive impairment at 6 months.

Yi Dong, Mengyuan Ding, Mei Cui, Min Fang, Li Gong, Zhuojun Xu, Yue Zhang, Xiuzhe Wang, Xiaofeng Xu, Xueyuan Liu and 3 more

Open access · hybridAbstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Yi DongDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Mengyuan DingDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Mei CuiDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Min FangDepartment of Neurology, The Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Li GongDepartment of Neurology, The Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Zhuojun XuDepartment of Neurology, The East Hospital Affiliated to Tongji University, Shanghai, China.
Yue ZhangDepartment of Neurology, The East Hospital Affiliated to Tongji University, Shanghai, China.
Xiuzhe WangDepartment of Neurology, The Six People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Xiaofeng XuDepartment of Neurology, The Six People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Xueyuan LiuDepartment of Neurology, The Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Gang LiDepartment of Neurology, The East Hospital Affiliated to Tongji University, Shanghai, China.
Yuwu ZhaoDepartment of Neurology, The Six People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Qiang DongDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Shanghai East Hospital · CNHuashan Hospital · CNShanghai Sixth People's Hospital · CNShanghai Tenth People's Hospital · CNFudan University · CNShanghai Jiao Tong University · CNState Key Laboratory of Medical NeurobiologyTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis multicenter, retrospective study assessed the prevalence of post-stroke cognitive impairment (PSCI) 6 months after acute ischemic stroke (AIS) and its risk factors to build a bedside early predictive model for PSCI using the Montreal Cognitive Assessment (MoCA).

methodsRecords of consecutive patients with AIS treated at 4 stroke centers in Shanghai had MoCA assessments within 2 weeks after AIS onset and 6 months later were reviewed. Prevalence of PSCI (MoCA<22) was calculated and risk factors were identified by multivariate logistic regression analysis. The modeling and validation and identified risk factors were included in a predictive model using multivariate regression.

resultsThere were 383 patients included and prevalence of PSCI 6 months after AIS was 34.2%, significantly lower than prevalence of patients with acute cognitive impairment (49.6%). Aging, less education, higher glucose level and severe stroke were PSCI risk factors, while level of low-density lipoprotein cholesterol (LDL-C) had a paradox effect on the risk of PSCI. 40.0% of the patients with cognitive impairment at acute phase reverted to normal, and patients with LDL-C 1.8-2.5 mmol/L were more likely to revert. The predictive model we built, DREAM-LDL (Diabetes [fasting blood glucose level], Rating [NIHSS], level of Education, Age, baseline MoCA and LDL-C level), had an AUROC of 0.93 for predicting PSCI at 6 months.

conclusionPSCI was common among AIS patients 6 months after AIS. We provided a practical tool to predict PSCI based on MoCA and risk factors present during acute phase of AIS.

Indexed as

AgedAged, 80 and overAge FactorsArea Under CurveChinaCognitive DysfunctionDiagnostic Tests, RoutineEducational StatusFemaleHumansLogistic ModelsMaleMental Status ScheduleMiddle AgedMultivariate AnalysisNeuropsychological Testsacute ischemic strokelow-density lipoprotein cholesterolpost-stroke cognitive impairmentrisk factorsthe Montreal cognitive assessment

Identifiers

PMID34506303
PMCPMC8457606
OpenAlexW3197447395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.