Evidence map›Paper›PMID 34506301›Full record

ArticleAging2021

Knock-down of

Ioan Valentin Matei, Vimbai Netsai Charity Samukange, Gabriela Bunu, Dmitri Toren, Simona Ghenea, Robi Tacutu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ioan Valentin MateiSystems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
Vimbai Netsai Charity SamukangeSystems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
Gabriela BunuSystems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
Dmitri TorenSystems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
Simona GheneaSystems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
Robi TacutuSystems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
Romanian Academy · ROInstitute of Biochemistry · RO

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Genetic manipulations can ameliorate the aging process and extend the lifespan of model organisms. The aim of this research was to identify novel genetic interventions that promote both lifespan and healthspan, by combining the effects of multiple longevity-associated gene inactivations in

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsEukaryotic Initiation FactorsForkhead Transcription FactorsGene Expression RegulationGene Knockdown TechniquesGTP-Binding Protein alpha Subunits, Gi-GoLongevityMutationRNA-Binding ProteinsRNA InterferenceCaenorhabditis elegans ProteinsCKU-70 protein, C elegansdaf-16 protein, C elegansDNA-Binding ProteinsEukaryotic Initiation FactorsForkhead Transcription FactorsGTP-Binding Protein alpha Subunits, Gi-Goife-2 protein, C elegansodr-3 protein, C elegansRNA-Binding Proteinsgenetic interventionsife-2lifespan extensionodr-3synergism

Identifiers

PMID34506301
PMCPMC8457566
OpenAlexW3197816540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.