ArticleAdipocyte2021
A novel immune-related genes signature after bariatric surgery is histologically associated with non-alcoholic fatty liver disease.
Article in Adipocyte, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- A Distinctive NAFLD Signature in Adipose Tissue from Women with Severe Obesity.International journal of molecular sciences · 2021Trial
- A nomogram for assessing the risk of MAFLD based on the albumin-to-gamma-glutamyl transferase ratio.European journal of medical research · 2025Article
- Insulin resistance as potential mediator linking ApoB/ApoA1 to MAFLD, but not inflammation.Therapeutic advances in endocrinology and metabolism · 2025Article
- Differential effects of systemic immune inflammation indices on hepatic steatosis and hepatic fibrosis: evidence from NHANES 1999-2018.BMC gastroenterology · 2024Article
- Integrative Analyses of Genes of Pediatric Non-alcoholic Fatty Liver Disease Associated with Energy Metabolism.Digestive diseases and sciences · 2024Article
- Association between operative position and postoperative nausea and vomiting in patients undergoing laparoscopic sleeve gastrectomy.World journal of gastrointestinal surgery · 2024Article
- Probiotic consumption and hepatic steatosis: results from the NHANES 2011-2016 and Mendelian randomization study.Frontiers in nutrition · 2024Article
- Association of systemic immune biomarkers with metabolic dysfunction-associated steatotic liver disease: a cross-sectional study of NHANES 2007-2018.Frontiers in nutrition · 2024Article
- Identification and experimental validation of autophagy-related genes in abdominal aortic aneurysm.European journal of medical research · 2023Article
- Article
- Regulatory network of metformin on adipogenesis determined by combining high-throughput sequencing and GEO database.Adipocyte · 2022Article
- Individuals Undergoing Bariatric Surgery Ameliorate Hepatic Steatosis: Evidence from NHANES 2015-2018.Obesity surgery · 2022Article
- Systemic immune-inflammation index is associated with hepatic steatosis: Evidence from NHANES 2015-2018.Frontiers in immunology · 2022Article
- Integrated Bioinformatics Analysis Identifies Robust Biomarkers and Its Correlation With Immune Microenvironment in Nonalcoholic Fatty Liver Disease.Frontiers in genetics · 2022Article
- Exploring the landscape, hot topics, and trends of bariatric metabolic surgery with machine learning and bibliometric analysis.Therapeutic advances in gastrointestinal endoscopyArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence shows that immune-related genes (IRGs) play an important role in bariatric surgery (BS). We identified differentially expressed immune-related genes (DEIRGs) of adipose tissue after BS by analysing the two expression profiles of GEO (GSE59034 and GSE29409). Subsequently, enrichment analysis, GSEA and PPI networks were examined to identify the hub IRGs and related pathways. The performance of the signature was evaluated by area under the curve (AUC) of the receiver operating characteristic (ROC). CIBERSORT algorithm was used to evaluate the relative abundance of infiltrated immune cells.42 DEIRGs were found between the GSE59034 and GSE29409 datasets. The AUC of the signature was 0.904 and 0.865 in the GSE58979 and GSE48452, respectively. Interestingly, the signature also showed good performance in diagnosing non-alcoholic fatty liver disease (NAFLD) (AUC was 0.834 and 0.800, respectively). The number of neutrophils, macrophages M2, macrophages M0 and dendritic cells activated decreased significantly. After BS, the infiltration of T cells regulatory, monocytes, mast cells resting and plasma cells in adipose tissue increased. The novel proposed IRGs signature reveals the underlying immune mechanism of BS and is a promising biomarker for distinguishing the severity of NAFLD. This will provide new insights into strategies for treating obesity and NAFLD.
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