Evidence map›Paper›PMID 34506228›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response.

Camryn L Johnson, Lance Riley, Matthew Bersi, MacRae F Linton, W David Merryman

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Camryn L JohnsonDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0001-8656-1447
Lance RileyDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0001-7863-364X
Matthew BersiDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0003-1848-4165
MacRae F LintonAtherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-9277-0453
W David MerrymanDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0001-9662-1503
Vanderbilt University · US

Funding

Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVIES, SEAN STEPHEN · 2014 to 2025
$24.7M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
Mechanobiology of Cardiopulmonary FibrosisR35HL135790 · NHLBI · VANDERBILT UNIVERSITY · PI MERRYMAN, WILLIAM D · 2017 to 2023
$5.5M
Molecular Regulation of AtherosclerosisR01HL146134 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2019 to 2022
$3.3M
Novel pathways controlling macrophage inflammation and resolution in atherosclerosisR01HL148137 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HOTAMISLIGIL, GOKHAN S · 2019 to 2022
$2.9M
Macrophage SR-BI Regulates Autophagy, Angiogenin and tRNA-derived small RNAsR01HL127173 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LINTON, MACRAE F, VICKERS, KASEY C · 2016 to 2019
$2.1M
Identification of immunotherapeutic targets in cardiovascular diseaseR00HL146951 · NHLBI · WASHINGTON UNIVERSITY · PI BERSI, MATTHEW RYAN · 2020 to 2022
$747k
Targeting Cadherin-11 for the Treatment of Calcific Aortic Valve DiseaseF32HL154596 · NHLBI · VANDERBILT UNIVERSITY · PI RILEY, LANCE · 2020 to 2021
$111k
Identification of immunotherapeutic targets in cardiovascular diseaseK99HL146951 · NHLBI · VANDERBILT UNIVERSITY · PI BERSI, MATTHEW RYAN · 2019 to 2019
$99k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL116263HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL127173HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL135790HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146134HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146951HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL148137HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL154596HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK059637NHLBI NIH HHS F32 HL154596NHLBI NIH HHS K99 HL146951NHLBI NIH HHS P01 HL116263NHLBI NIH HHS R00 HL146951NHLBI NIH HHS R01 HL127173NHLBI NIH HHS R01 HL146134NHLBI NIH HHS R01 HL148137NHLBI NIH HHS R35 HL135790NIDDK NIH HHS U24 DK059637
6 · The paper itself

Abstract

Inflammation caused by infiltrating macrophages and T cells promotes plaque growth in atherosclerosis. Cadherin-11 (CDH11) is a cell-cell adhesion protein implicated in several fibrotic and inflammatory diseases. Much of the research on CDH11 concerns its role in fibroblasts, although its expression in immune cells has been noted as well. The objective of this study was to assess the effect of CDH11 on the atherosclerotic immune response. In vivo studies of atherosclerosis indicated an increase in

Indexed as

ChemotaxisPlaque, AtheroscleroticAnimalsAortaAortic DiseasesAtherosclerosisBone Marrow TransplantationCadherinsDisease Models, AnimalFemaleLymphocyte ActivationMacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoECadherinsosteoblast cadherinatherosclerosiscadherin-11macrophage

Identifiers

PMID34506228
PMCPMC8794229
OpenAlexW3198181083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.