Evidence map›Paper›PMID 34505934›Full record

ArticleZeitschrift fur Rheumatologie2021

[Treatment of lung fibrosis in systemic rheumatic diseases (new treatment)].

Katharina Buschulte, Anna-Maria Hoffmann-Vold, Rucsan Dra Dobrota, Philipp Höger, Andreas Krause, Michael Kreuter

Open access · bronzeAbstract read
In one paragraph

Article in Zeitschrift fur Rheumatologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Pulmonary Involvement in Autoimmune-Mediated Disease.Deutsches Arzteblatt international · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Katharina BuschulteZentrum für seltene und interstitielle Lungenerkrankungen, Pneumologie, Thoraxklinik, Universitätsklinikum Heidelberg und Deutsches Zentrum für Lungenforschung (DZL), Röntgenstr. 1, 69126, Heidelberg, Deutschland.
Anna-Maria Hoffmann-VoldDepartment of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norwegen.
Rucsan Dra DobrotaKlinik für Rheumatologie, Universitätsspital Zürich, Zürich, Schweiz.
Philipp HögerZentrum für seltene und interstitielle Lungenerkrankungen, Pneumologie, Thoraxklinik, Universitätsklinikum Heidelberg und Deutsches Zentrum für Lungenforschung (DZL), Röntgenstr. 1, 69126, Heidelberg, Deutschland.
Andreas KrauseAbteilung für Rheumatologie, Klinische Immunologie und Osteologie, Immanuel Krankenhaus Berlin, Berlin, Deutschland.
Michael KreuterZentrum für seltene und interstitielle Lungenerkrankungen, Pneumologie, Thoraxklinik, Universitätsklinikum Heidelberg und Deutsches Zentrum für Lungenforschung (DZL), Röntgenstr. 1, 69126, Heidelberg, Deutschland. kreuter@uni-heidelberg.de.
German Center for Lung Research · DEHeidelberg University · DEImmanuel Krankenhaus · DEOslo University Hospital · NOUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An interstitial lung disease represents a relevant organ manifestation in many systemic rheumatic diseases (connective tissue disease-interstitial lung disease, CTD-ILD). In 10% of the cases pulmonary fibrosis even results in an underlying systemic disease. The CTD-ILDs are frequently associated with a poor prognosis. Therefore, it is important to test patients with systemic rheumatic diseases timely and regularly for the presence of an ILD. Treatment decisions should be made together with pneumologists and rheumatologists, particularly with respect to the initiation of a specific treatment. Treatment is based on randomized studies only in a few cases and can mostly be derived from case control studies. For systemic sclerosis-associated ILD (SSc-ILD) antifibrotic treatment with nintedanib has also now been approved in addition to an immunosuppressive treatment. For other CTD-ILDs an antifibrotic treatment should be discussed in an interdisciplinary approach depending on the underlying disease corresponding to a progressively fibrosing ILD.

Indexed as

Connective Tissue DiseasesLung Diseases, InterstitialPulmonary FibrosisRheumatic DiseasesScleroderma, SystemicHumansAntifibrotic treatmentImmunosuppressionInterstitial pneumonia with autoimmune featuresRheumatoid arthritis with interstitial lung diseaseSystemic sclerosis-associated interstitial lung diseases

Identifiers

PMID34505934
PMCPMC8429885
OpenAlexW3198657468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.