ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2022
Stress on the posteromedial region of the proximal tibia increased over time after anterior cruciate ligament injury.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 12 citations in OpenAlex.
- Translating mechanobiology in osteoarthritis to biomaterial-informed therapeutic strategies.Mechanobiology in medicine · 2026Review
- Alteration of Subchondral Bone Density Distribution Across the Knee Joint Before and After Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2026Article
- No significant side-to-side differences in retropatellar load distribution using more than 7.5 years after isolated MPFL reconstruction: A CT-osteoabsorptiometry pilot study in nine patients.Journal of experimental orthopaedics · 2026Article
- Characterization of time-dependent changes in the subchondral bone density distribution of the proximal tibia following high tibial osteotomy.Journal of experimental orthopaedics · 2025Article
- The Relationship of Meniscal Extrusion to Subchondral Bone Density in Medial Knee Osteoarthritis.Orthopaedic journal of sports medicine · 2025Article
- Individual and Combined Effects of Anterior Cruciate Ligament and Lateral Meniscus Injuries and Surgical Interventions on Tibiofemoral Peak Pressure Magnitude Vary by Flexion Angle.Arthroscopy, sports medicine, and rehabilitation · 2025Article
- Combined PCL instabilities cannot be identified using posterior stress radiographs in external or internal rotation: A cadaveric study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Investigation of the anatomic risk factors in acute anterior cruciate ligament ruptures to develop ramp lesions of the medial meniscus by quantitative MRI.Insights into imaging · 2024Article
- Computed tomography Osteoabsorptiometry: Review of bone density, mechanical strength of material and clinical application.Frontiers in bioengineering and biotechnology · 2023Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnterior cruciate ligament (ACL) injury induces anterior and rotatory instability of the knee. However, the effect of this instability on the stress distribution in the knee joint in living participants is not clear. The aim of this study was to compare the distribution pattern of subchondral bone density across the proximal tibia in the knees with and without ACL injury, and to investigate the correlation between the distribution patterns of the subchondral bone density and the duration of ACL-deficiency.
methodsRadiographic and computed tomography (CT) data pertaining to 20 patients with unilateral ACL injury without combined injury (ACL-deficient group) and 19 nontraumatic subjects (control group) were collected retrospectively. Subchondral bone density of the proximal tibia was assessed using CT-osteoabsorptiometry. Both the medial and lateral compartments of the proximal tibia were divided into three subregions of equal width in the sagittal direction. The percentage of high subchondral bone density areas (HDA%) in each subregion was quantitatively analyzed.
resultsHDA% of the posteromedial region was significantly higher in the ACL-deficient group (mean: 21.6%) than in the control group (14.7%) (p = 0.002). In contrast, HDA% of the anteromedial region was significantly lower in the ACL-deficient group (9.4%) than in the control group (15.3%) (p = 0.048). The logarithm of the time elapsed from ACL injury to CT examination showed a significant correlation with HDA% in the posteromedial region (p = 0.032).
conclusionsSubchondral bone density in the posteromedial region significantly increased after ACL injury and correlated with the duration of ACL-deficiency in semi-log manner in meniscus intact knees. The increase in stress on the posteromedial region after ACL injury, which induces a change in the subchondral bone density, justifies early ACL reconstruction after ACL injury.
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