Evidence map›Paper›PMID 34505919›Full record

Trial reportEuropean journal of nutrition2022

Fortifying a meal with oyster mushroom powder beneficially affects postprandial glucagon-like peptide-1, non-esterified free fatty acids and hunger sensation in adults with impaired glucose tolerance: a double-blind randomized controlled crossover trial.

Lisa Dicks, Linda Jakobs, Miriam Sari, Reinhard Hambitzer, Norbert Ludwig, Marie-Christine Simon, Peter Stehle, Birgit Stoffel-Wagner, Hans-Peter Helfrich, Jenny Ahlborn and 4 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05594329 (A Randomized Controlled Trial to Investigate the Neurological, Inflammatory and Metabolic Effects of Acute Mushroom Intervention in Older Adults), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05594329 nacompletednot on this map

A Randomized Controlled Trial to Investigate the Neurological, Inflammatory and Metabolic Effects of Acute Mushroom Intervention in Older Adults (OYSACO)

TypeinterventionalSponsorUniversity of ReadingRan2022 to 2022Enrolled33ConditionsCognitive Change, Mood, Metabolism, Inflammatory ResponseArmsInstant noodle soup containing containing the equivalent of 2 servings (18.78g) of powdered Pleurotus oyster mushroom., Instant noodle soup containing containing the equivalent of 1 serving (9.39g) of powdered Pleurotus oyster mushroom., Instant noodle soup containing containing the equivalent of 0.5 serving (4.70g) of powdered Pleurotus oyster mushroom., Control instant noodle soup
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. The Health and Clinical Benefits of Medicinal Fungi.Advances in biochemical engineering/biotechnology · 2023
    Article
  10. Review
  11. A Randomized Controlled Trial onAntioxidants (Basel, Switzerland) · 2022
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Lisa DicksDepartment of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
Linda JakobsDepartment of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
Miriam SariDepartment of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
Reinhard HambitzerDepartment of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
Norbert LudwigDepartment of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
Marie-Christine SimonDepartment of Nutrition and Food Sciences, Nutrition and Microbiota, University of Bonn, Bonn, Germany.
Peter StehleDepartment of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
Birgit Stoffel-WagnerInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Hans-Peter HelfrichInstitute of Numerical Simulation, University of Bonn, Bonn, Germany.
Jenny AhlbornInstitute of Food Chemistry and Food Biotechnology, University of Giessen, Giessen, Germany.
Martin RühlInstitute of Food Chemistry and Food Biotechnology, University of Giessen, Giessen, Germany.
Bolette HartmannNNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jens J HolstNNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sabine EllingerDepartment of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany. ellinger@uni-bonn.de.ORCID http://orcid.org/0000-0002-9988-9406
University of Bonn · DEHochschule Niederrhein · DEJustus-Liebig-Universität Gießen · DEUniversity of Copenhagen · DKUniversity Hospital Bonn · DE

Funding

Bundesministerium für Bildung und Forschung FKZ 01EA1707Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen 322-8.03.04.02-FH-STRUKTUR 2016/01
6 · The paper itself

Abstract

purposeImpaired glucose tolerance (IGT) is a pathophysiological condition characterized by insulin resistance with known metabolic consequences such as postprandial hyperglycemia and hypertriglyceridemia. We hypothesized that fortifying a meal with mushrooms rich in β-glucans may diminish glucose and triglyceride responses by improving postprandial gastrointestinal hormone release.

methodsIn a randomized controlled crossover study, 22 subjects with IGT ingested a meal either enriched with 20 g powder (8.1 g β-glucans) of oven-dried Pleurotus ostreatus (enriched meal, EN) or without enrichment (control meal, CON). Blood was collected before and repeatedly within 4 h after the meal to determine AUC of glucose (primary outcome), insulin, triglycerides, non-esterified free fatty acids (NEFAs), glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP) and ghrelin. Appetite sensations (hunger, satiety, fullness, and desire to eat) were assessed before and after meal consumption by visual analog scales.

resultsPostprandial glucose, insulin, triglycerides, GIP and ghrelin concentrations as well as the corresponding AUCs did not differ between EN and CON. NEFAs-AUC was 14% lower (P = 0.026) and GLP-1-AUC 17% higher (P = 0.001) after EN compared to CON. Appetite ratings did not differ between treatments, except for hunger (AUC 22% lower after EN vs. CON; P = 0.031).

conclusionThe observed immediate postprandial metabolic changes indicate that an easily manageable fortification of a single meal with powder from dried oyster mushrooms as β-glucan source may improve postprandial metabolism. If the effect is preserved long term, this measure can diminish the risk for further development of overweight/obesity and type 2 diabetes in subjects with IGT. CLINICAL

trial registrationGerman Clinical Trial Register on 09/08/2018; trial-ID: DRKS00015244.

Indexed as

Diabetes Mellitus, Type 2Glucose IntolerancePleurotusAdultBlood GlucoseCross-Over StudiesFatty Acids, NonesterifiedGlucagon-Like Peptide 1HumansHungerInsulinPostprandial PeriodPowdersSensationBlood GlucoseFatty Acids, NonesterifiedGlucagon-Like Peptide 1InsulinPowdersAppetite sensationsGastrointestinal hormonesImpaired glucose toleranceOyster mushroomsPostprandial glucose and lipid metabolismβ-Glucans

Identifiers

PMID34505919
PMCPMC8854321
OpenAlexW3196808915

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.