Evidence map›Paper›PMID 34505916›Full record

Trial reportClinical oral investigations2022

Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid.

Rafael Simões Gonçalves, Polliana Mendes Candia Scaffa, Mirela Sanae Shinohara, Paulo Roberto Marão de Andrade Carvalho, Marília Afonso Rabelo Buzalaf, Ticiane Cestari Fagundes

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Zymography as a Tool for Exploring Protease Activity in Dental Research.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rafael Simões GonçalvesAraçatuba School of Dentistry, São Paulo State University, José Bonifácio St, 1193, Araçatuba, SP, 16015-050, Brazil.
Polliana Mendes Candia ScaffaOregon Health and Science University, SW Sam Jackson Park Rd, OR 97239, Portland, OR, 3181, USA.
Mirela Sanae ShinoharaAraçatuba School of Dentistry, São Paulo State University, José Bonifácio St, 1193, Araçatuba, SP, 16015-050, Brazil.
Paulo Roberto Marão de Andrade CarvalhoAraçatuba School of Dentistry, São Paulo State University, José Bonifácio St, 1193, Araçatuba, SP, 16015-050, Brazil.
Marília Afonso Rabelo BuzalafBauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla St., 9-75 - Jardim Brasil, Bauru, SP, 17012-901, Brazil.
Ticiane Cestari FagundesAraçatuba School of Dentistry, São Paulo State University, José Bonifácio St, 1193, Araçatuba, SP, 16015-050, Brazil. ticiane.fagundes@unesp.br.ORCID http://orcid.org/0000-0002-3418-0498
Universidade Estadual Paulista (Unesp) · BROregon Health & Science University · USUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 447616/2014-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/07086-0
6 · The paper itself

Abstract

objectivesTo evaluate different restorative techniques for non-carious cervical lesions (NCCLs) and the activity of matrix metalloproteinases (MMPs) in gingival crevicular fluid. MATERIALS AND

methodsTwo hundred restorations were performed in 50 patients using resin composite restorative system without (I) and with selective enamel conditioning (II) and resin-modified glass-ionomer cement without (III) and with EDTA pretreatment (IV). Gingival crevicular fluid samples were collected in 15 patients. Restorations were evaluated using USPHS criteria at baseline and after 2 years. Percentages of MMP activity were assessed by zymography as a surrogate outcome. Equality tests of two proportions, logistic regression analysis, survival analysis, ANOVA repeated measures, and Fisher tests were used.

resultsNo differences in clinical performance were found among groups. Group I had lower retention at 2 years than at baseline. Decreased alpha scores for marginal integrity and marginal discoloration were observed for all groups after 2 years. MMP-2 decreased after 1 year, and its activity increased back to the initial level after 2 years, mainly for groups I, II, and III. MMP-9 increased after 1 year, and it was reduced to the initial level after 2 years, mainly for group I.

conclusionsAll restorative techniques performed similarly in NCCLs after 2 years with initial marginal defect alterations. MMP-2 reestablished its initial levels after 2 years, and MMP-9 had few alterations over time in crevicular fluid. Clinical relevance The different restorative techniques are equally successful in NCCLs after 2 years of clinical functioning and have similar effects on MMPs present in crevicular fluid.

Indexed as

Dental Restoration, PermanentGingival Crevicular FluidComposite ResinsDental Marginal AdaptationGlass Ionomer CementsHumansMatrix MetalloproteinasesResin CementsComposite ResinsGlass Ionomer CementsMatrix MetalloproteinasesResin CementsClinical trialGingival crevicular fluidGlass-ionomer cementMatrix metalloproteinasesNon-carious cervical lesionsResin composite

Identifiers

PMID34505916
OpenAlexW3198256029

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.