ReviewIntensive care medicine2022
Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications.
Review in Intensive care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Advanced resuscitation strategies for cardiac arrest in pregnancy: a systematic review.BMC cardiovascular disorders · 2026Pooled it
- Concomitant Intra-Aortic Balloon Pump Throughout Extracorporeal Cardiopulmonary Resuscitation: A Meta-Analysis of Cohorts.Reviews in cardiovascular medicine · 2026Pooled it
- Survival and neurological outcome in patients treated with extracorporeal membrane oxygenation and therapeutic hypothermia: an updated systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Neurological outcome predictors after extracorporeal cardiopulmonary resuscitation: a systematic review.Systematic reviews · 2025Pooled it
- Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation and immediate invasive assessment in refractory out-of-hospital cardiac arrest: a long-term follow-up of the Prague OHCA trial.Critical care (London, England) · 2024Trial
- ECPR readiness without perfusionist support: a cross-sectional national survey on circuit preparation, team structure, and training.BMC emergency medicine · 2026Article
- From arrest to circuit: Mapping twenty years of progress and pitfalls in ECPR implementation, patient selection, and initiation timing☆.The journal of extra-corporeal technology · 2026Review
- Incidence and impact of loss of pulsatility on outcomes after extracorporeal cardiopulmonary resuscitation - A retrospective cohort study.Resuscitation plus · 2026Article
- The effect of initial rhythm on patient outcome in refractory cardiac arrest requiring extracorporeal cardiopulmonary resuscitation: A retrospective, multicentre registry cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Evaluating the impact of implementing an ECPR protocol on prehospital resuscitation quality: a randomized controlled simulation study.Advances in simulation (London, England) · 2026Article
- Ethics in prehospital extracorporeal cardiopulmonary resuscitation.Resuscitation plus · 2026Article
- Optimizing Regional Access to Extracorporeal Cardiopulmonary Resuscitation: A Geographic-Information-System-Based Comparison of Hospital- and Prehospital-Initiated Strategies in Nara Prefecture, Japan.Healthcare (Basel, Switzerland) · 2026Article
- Optimizing Extracorporeal Cardiopulmonary Resuscitation Candidate Selection in out-of-Hospital Cardiac Arrest: A Machine-Learning Individualized Treatment Effect Approach Versus Rule-Based Criteria.Journal of the American Heart Association · 2026Article
- Estimating bystander CPR using a strict documentation-based definition: a multiregional EMS registry analysis.BMC emergency medicine · 2026Observational
- [Good outcome after out of hospital cardiac arrest despite unfavorable prognosis and without using eCPR].Die Anaesthesiologie · 2026Article
- Sigma-1 receptor agonist SA4503 improves cerebral protective effects in an extracorporeal cardiopulmonary resuscitation rat model.JTCVS open · 2026Article
- Successful ECPR in Treating a Case of Chlorine Gas Poisoning Leading to ARDS and Cardiac Arrest.Clinical case reports · 2026Article
- Current rat models of extracorporeal life support following global ischaemia: a scoping review.Intensive care medicine experimental · 2026Review
- Extracorporeal Cardiopulmonary Resuscitation as a Bridge to Cardiac Transplantation in Refractory Cardiac Arrest Due to Fulminant Myocarditis: A Case Report.International medical case reports journal · 2026Article
- No Pulse, No Panic! Navigating Cardiac Arrest in LVAD-Supported Patients.Critical care clinics · 2026Review
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rates of survival with functional recovery for both in-hospital and out-of-hospital cardiac arrest are notably low. Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a modality to improve prognosis by augmenting perfusion to vital end-organs by utilizing extracorporeal membrane oxygenation (ECMO) during conventional CPR and stabilizing the patient for interventions aimed at reversing the aetiology of the arrest. Implementing this emergent procedure requires a substantial investment in resources, and even the most successful ECPR programs may nonetheless burden healthcare systems, clinicians, patients, and their families with unsalvageable patients supported by extracorporeal devices. Non-randomized and observational studies have repeatedly shown an association between ECPR and improved survival, versus conventional CPR, for in-hospital cardiac arrest in select patient populations. Recently, randomized controlled trials suggest benefit for ECPR over standard resuscitation, as well as the feasibility of performing such trials, in out-of-hospital cardiac arrest within highly coordinated healthcare delivery systems. Application of these data to clinical practice should be done cautiously, with outcomes likely to vary by the setting and system within which ECPR is initiated. ECPR introduces important ethical challenges, including whether it should be considered an extension of CPR, at what point it becomes sustained organ replacement therapy, and how to approach patients unable to recover or be bridged to heart replacement therapy. The economic impact of ECPR varies by health system, and has the potential to outstrip resources if used indiscriminately. Ideally, studies should include economic evaluations to inform health care systems about the cost-benefits of this therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.