ArticleMolecular medicine reports2021
Amelioration of alcohol‑induced gastric mucosa damage by oral administration of food‑polydeoxyribonucleotides.
Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Comparative evaluation of the gastroprotective effects of lactic acid bacteria strains against ethanol/HCl-induced gastric injury.Food science of animal resources · 2026Article
- Lactiplantibacillus plantarum DS1073 protects the gastric mucosa under Helicobacter pylori infection and ethanol stress.Cell communication and signaling : CCS · 2026Article
- Yeokwisan: Standardised Herbal Formula Enhancing Gastric Mucosal Protection Against Gastric Ulcers in Mice, a Preclinical Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Protective effect ofMicrobiology spectrum · 2024Article
- Protective role of fruits ofChinese herbal medicines · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastritis refers to inflammation caused by injury to the gastric epithelium, which is usually due to excessive alcohol consumption and prolonged use of nonsteroidal anti‑inflammatory drugs. Millions of individuals worldwide suffer from this disease. However, the lack of safe and promising treatments makes it urgent to explore and develop leads from natural resources. Therefore, food as medicine may be the best approach for the treatment of these disorders. The present study described the protective effects of food‑polydeoxyribonucleotides (f‑PDRNs) in a rat model of gastric mucosal injury induced by HCl‑EtOH. Administration of f‑PDRN was performed with low‑PRF002 (26 mg/kg/day), medium‑PRF002 (52 mg/kg/day) and high‑PRF002 (78 mg/kg/day) on the day of autopsy. The site of damage to the mucous membrane was also analysed. In addition, an increase in gastric juice pH, total acidity of gastric juice and decrease in gastric juice secretion were confirmed, and gastric juice secretion‑related factors corresponding to the administration of f‑PDRN were analysed. Administration of f‑PDRN reduced the mRNA expression of histamine H2 receptor, muscarinic acetylcholine receptor M3, cholecystokinin 2 receptor and H
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