Evidence map›Paper›PMID 34505420›Full record

ArticleEndocrinology, diabetes & metabolism2021

Risk of mortality among inpatients with COVID-19 and type 2 diabetes: National data from Kuwait.

Ebaa Al-Ozairi, Rosemary Brown, Yasmine Hamdan, Lulwa Alabdullah, Nia Voase, Jumana Al Kandari, Dalal Alsaeed, Abdulla Al Ozairi, Amal Hasan, Fahd Al-Mulla and 6 more

Abstract read
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus-A Retrospective Study.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Diabetes and SARS-CoV-2-Is There a Mutual Connection?Frontiers in cell and developmental biology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ebaa Al-OzairiClinical Research Unit, Dasman Diabetes Institute, Dasman, Kuwait.
Rosemary BrownInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Yasmine HamdanClinical Research Unit, Dasman Diabetes Institute, Dasman, Kuwait.
Lulwa AlabdullahInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Nia VoaseClinical Research Unit, Dasman Diabetes Institute, Dasman, Kuwait.
Jumana Al KandariClinical Research Unit, Dasman Diabetes Institute, Dasman, Kuwait.
Dalal AlsaeedClinical Research Unit, Dasman Diabetes Institute, Dasman, Kuwait.
Abdulla Al OzairiDepartment of Psychiatry, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Amal HasanClinical Research Unit, Dasman Diabetes Institute, Dasman, Kuwait.
Fahd Al-MullaDepartment of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman, Kuwait.
Srinivasa Vittal KatikireddiPublic Health, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Stuart R GrayInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0001-8969-9636
Jason M R GillInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Carlos A Celis-MoralesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-1604-2593
Paul WelshInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-7970-3643

Funding

British Heart Foundation Centre of Research RE/18/6/34217Chief Scientist Office SCAF/15/02Dasman Diabetes InstituteKuwait Foundation for Advancement of ScienceKuwait Ministry of HealthMedical Research Council MC_UU_00022/2Medical Research Council MC_UU_12017/13Medical Research Council Doctoral Training Programme studentship in Precision Medicine MR/N013166/1NRS Senior Clinical Fellowship SCAF/15/02Scottish Government Chief Scientist Office SPHSU17
6 · The paper itself

Abstract

introductionTo investigate type 2 diabetes as a risk factor for COVID-19 death following hospital admission in Kuwait.

methodsA retrospective cohort study using data from a central hospital that cared for all hospitalized COVID-19 patients in Kuwait. We investigated the association between type 2 diabetes, with COVID-19 mortality using multiply imputed logistic regression and calculated the population attributable fraction.

resultsA total of 5333 patients were admitted with COVID-19, of whom 244 died (4.6%). Diabetes prevalence was 24.8%, but 53.7% of those who died had diabetes. After adjusting for age, sex, ethnicity and other comorbidities, diabetes was associated with death (OR 1.70 [95% CI 1.23, 2.34]) and admission to the intensive care unit more than 3 days after initial admission (OR 1.78 [95% CI 1.17, 2.70]). Assuming causality, the population attributable fraction for type 2 diabetes in COVID-19 death was 19.6% (95% CI 10.8, 35.6).

conclusionType 2 diabetes is a strong risk factor for COVID-19 death in the Middle East. Given the high prevalence of type 2 diabetes in the Middle East, as well as many Western countries, the public health implications are considerable.

Indexed as

AdultAgedComorbidityCOVID-19Diabetes Mellitus, Type 2FemaleHospitalizationHospital MortalityHumansInpatientsIntensive Care UnitsKuwaitMaleMiddle AgedPrevalenceRetrospective StudiesCOVID-19deathdiabetes

Identifiers

PMID34505420
PMCPMC8420596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.