ArticleEndocrinology, diabetes & metabolism2021
Association of estimated glucose disposal rate and chronic diabetic complications in patients with type 1 diabetes.
Article in Endocrinology, diabetes & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Estimated glucose disposal rate and microvascular complications of diabetes mellitus type I: A systematic review and meta-analysis.Diabetes & vascular disease researchPooled it
- Insulin resistance in type 1 diabetes: the silent burden unmasked by eGDR.Acta diabetologica · 2026Article
- Association Between Estimated Glucose Disposal Rate and Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Zhejiang, China.Clinical interventions in aging · 2026Article
- Estimated Glucose Disposal Rate: A Potential Determinant for Microvascular and Macrovascular Complications in Type 2 Diabetes.Endocrinology, diabetes & metabolism · 2025Article
- Association of estimated glucose disposal rate with atrial fibrillation, heart failure and cardiovascular mortality in patients with diabetes: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2025Article
- Association between estimated glucose disposal rate and metabolic syndrome: a cross-sectional analysis of the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
- Safety and Efficacy of Eucaloric Very Low-Carb Diet (EVLCD) in Type 1 Diabetes: A One-Year Real-Life Retrospective Experience.Nutrients · 2022Article
- Association of estimated glucose disposal rate and chronic diabetic complications in patients with type 1 diabetes.Endocrinology, diabetes & metabolism · 2021Article
- Epigallocatechin Gallate Induces the Demethylation of Actinin Alpha 4 to Inhibit Diabetic Nephropathy Renal Fibrosis via the NF-KB Signaling Pathway In Vitro.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe role of insulin resistance in diabetic chronic complications among individuals with type 1 diabetes (T1D) has not been clearly defined. The aim of this study was to examine the performance of insulin resistance, evaluated using the estimated glucose disposal rate (eGDR) for the identification of metabolic syndrome (MS) and diabetic chronic complications.
methodsCross-sectional study in a tertiary care centre. We included patients of 18 years and older, with at least 6 months of T1D duration. Anthropometric, clinical and biochemical data were collected.
resultsSeventy patients, 41 (58.6%) women, with a median age of 36.6 years (range 18-65). Mean age of onset and duration of diabetes was 13.5 ± 6.5 and 23.6 ± 12.2 years, respectively. Twenty-one (30%) patients met the metabolic syndrome (MS) criteria. Patients with MS had lower eGDR compared to patients without (5.17 [3.10-8.65] vs. 8.86 [6.82-9.85] mg/kg/min, respectively, p = .003). Median eGDR in patients with nephropathy, retinopathy and neuropathy compared with those without was 6.75 (4.60-8.20) versus 9.53 (8.57-10.3); p < .001, 6.45 (4.60-7.09) versus 9.50 (8.60-10.14); p < .001, 5.56 (4.51-6.81) versus 9.49 [8.19-10.26] mg/kg/min; p < .001, respectively. The eGDR showed an area under the curve of 0.909, 0.879, 0.897 and 0.836 for the discrimination of MS, retinopathy, neuropathy and nephropathy, respectively.
conclusionsPatients with T1D diabetic complications have higher insulin resistance. The eGDR discriminates patients with chronic diabetic complications and MS. While more ethnic-specific studies are required, this study suggests the possibility to incorporate eGDR into routine diabetes care.
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