Evidence map›Paper›PMID 34505400›Full record

ArticleVeterinary medicine and science2021

First neuroinvasive human case of West Nile Disease in Southern Italy: Results of the 'One Health' approach.

Giusi Macaluso, Francesca Gucciardi, Annalisa Guercio, Valeria Blanda, Francesco La Russa, Alessandra Torina, Francesco Mira, Santina Di Bella, Antonio Lastra, Ilenia Giacchino and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Veterinary medicine and science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Endemic progression of autochthonous West Nile virus infections in Europe.European journal of microbiology & immunology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Giusi MacalusoIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Francesca GucciardiIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Annalisa GuercioIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Valeria BlandaIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Francesco La RussaIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Alessandra TorinaIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Francesco MiraIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Santina Di BellaIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Antonio LastraIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Ilenia GiacchinoIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Calogero CastronovoIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Giustina VitaleU.O. Dipartimento Diagnostica Specialistica Patologie Diffusive, Regional Reference Center for diseases transmitted by arthropods, Azienda Ospedaliera Universitaria "P. Giaccone", Palermo, Italy.
Giuseppa PurpariIstituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Palermo, Italy.
Istituto Zooprofilattico Sperimentale Della Sicilia · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWest Nile Disease (WND) is a zoonotic mosquito-borne infection involving viral pathogens, human and animal hosts, vectors and environment. Cooperation among medical, veterinary and entomological fields has been promoted by the Italian Public Health Authorities, and an integrated West Nile Virus (WNV) Surveillance Plan has been in force in Italy since 2016 to prevent the transmission risk of WND to humans through an early detection of viral circulation by animal and entomological surveillance. This managing model is unique in Europe.

objectivesThis survey aimed at presenting the 'One Health' approach applied in 2016 to the first autochthonous human case of West Nile Neuroinvasive Disease (WNND) in Sicily (Southern Italy).

methodsSerological (anti-WNV IgM and IgG ELISA, anti-WNV neutralizing antibodies) and molecular tests were conducted on blood, liquor and urine of a 38-year-old man with encephalitis and meningitis. Overall, 2704 adult culicides from 160 mosquito catches were morphologically identified. Female mosquitoes were analysed in pools for WNV RNA detection. Serological (anti-WNV IgM and IgG ELISA) and molecular analyses for WNV were carried out in 11 horses, 271 chickens and two dogs sampled in farms around the man's residence. RESULTS AND

conclusionsWNND was confirmed by serological analysis on patient's liquor and serum. Collected mosquito species included Culex pipiens (93.56%, CI

Indexed as

Dog DiseasesHorse DiseasesOne HealthWest Nile FeverWest Nile virusAnimalsChickensDogsFemaleHorsesHumansMosquito Vectorshuman caseIntegrated Surveillance SystemItalymosquito‘One Health’West Nile Virus

Identifiers

PMID34505400
PMCPMC8604128
OpenAlexW3197481699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.