Evidence map›Paper›PMID 34505377›Full record

ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2021

The clinical characterization of the adult patient with an anxiety or related disorder aimed at personalization of management.

Dan J Stein, Michelle G Craske, Barbara O Rothbaum, Samuel R Chamberlain, Naomi A Fineberg, Karmel W Choi, Peter de Jonge, David S Baldwin, Mario Maj

Open access · bronzeAbstract read
In one paragraph

Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  7. Article
  8. Article
  9. Article
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  12. Article
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  14. Review
  15. The current clinical approach to feeding and eating disorders aimed to increase personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Article
  16. Article
  17. Article
  18. The definition of treatment resistance in anxiety disorders: a Delphi method-based consensus guideline.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 6 countries.

Dan J SteinSouth African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Michelle G CraskeDepartment of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, (UCLA), Los Angeles, CA, USA.
Barbara O RothbaumDepartment of Psychiatry, Emory University, Atlanta, GA, USA.
Samuel R ChamberlainClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, and Southern Health NHS Foundation Trust, Southampton, UK.
Naomi A FinebergSchool of Life and Medical Sciences, University of Hertfordshire, and Hertfordshire Partnership University NHS Foundation Trust, Hatfield, UK.
Karmel W ChoiDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Peter de JongeDevelopmental Psychology, Department of Psychology, Rijksuniversiteit Groningen, Groningen, The Netherlands.
David S BaldwinClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, and Southern Health NHS Foundation Trust, Southampton, UK.
Mario MajDepartment of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.
University of Southampton · GBEmory University · USHertfordshire Partnership University NHS Foundation Trust · GBMassachusetts General Hospital · USUniversity of California, Los Angeles · USUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Cape Town · ZAUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical construct of "anxiety neurosis" was broad and poorly defined, so that the delineation of specific anxiety disorders in the DSM-III was an important advance. However, anxiety and related disorders are not only frequently comorbid, but each is also quite heterogeneous; thus diagnostic manuals provide only a first step towards formulating a management plan, and the development of additional decision support tools for the treatment of anxiety conditions is needed. This paper aims to describe systematically important domains that are relevant to the personalization of management of anxiety and related disorders in adults. For each domain, we summarize the available research evidence and review the relevant assessment instruments, paying special attention to their suitability for use in routine clinical practice. We emphasize areas where the available evidence allows the clinician to personalize the management of anxiety conditions, and we point out key unmet needs. Overall, the evidence suggests that we are becoming able to move from simply recommending that anxiety and related disorders be treated with selective serotonin reuptake inhibitors, cognitive-behavioral therapy, or their combination, to a more complex approach which emphasizes that the clinician has a broadening array of management modalities available, and that the treatment of anxiety and related disorders can already be personalized in a number of important respects.

Indexed as

Anxietyanxiety and related disordersclinical subtypesdysfunctional cognitive schemasearly environmental exposuresfamily historyfunctioningneurocognitionobsessive-compulsive disorderpersonality traitspersonalization of treatmentphysical comorbiditiespost-traumatic stress disorderprotective factorspsychiatric antecedentspsychiatric comorbiditiesquality of liferecent environmental exposuresseveritysymptom profile

Identifiers

PMID34505377
PMCPMC8429350
OpenAlexW3198484046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.