ArticleBritish journal of clinical pharmacology2022
Pregabalin poisoning: Evaluation of dose-toxicity relationship.
Article in British journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Pregabalin-associated adverse drug reactions: A real-world pharmacovigilance study using WHO-VigiAccess.Medicine · 2026Article
- Probable pregabalin and amantadine-containing cold medication intoxication in an adolescent with rhabdomyolysis: Case report.Journal of Taibah University Medical Sciences · 2026Article
- Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study.PLoS medicine · 2026Article
- Case Report: High-dose pregabalin ingestion in an adolescent: clinical course and serial plasma concentrations.Frontiers in toxicology · 2026Article
- Second-Degree Atrioventricular Block Following Acute Pregabalin Intoxication: A Case Report.Cureus · 2026Article
- Case report: A comatose patient with pregabalin overdose successfully treated with continuous renal replacement therapy.Frontiers in medicine · 2023Article
- Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study.International journal of general medicine · 2023Article
- Pregabalin poisoning: Evaluation of dose-toxicity relationship.British journal of clinical pharmacology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPregabalin poisoning is mostly benign, although coma and convulsions occasionally occur.
aimTo determine the dose-toxicity relationship of pregabalin.
methodsDose-toxicity data of isolated pregabalin poisonings were collected from (1) a prospective study performed by the Dutch Poisons Information Centre (4 April 2014 to 4 October 2016) and from (2) case reports and case series reported in literature. Poisonings were graded using the Poisoning Severity Score (PSS) and the relationship between dose (mg kg
resultsIn our study (n = 21 patients), the most commonly observed symptoms were drowsiness (62%), confusion (29%) and apathy (24%). PSS was none in three (14%), minor in 15 (71%), and moderate in three patients (14%). Most case series also reported a PSS of none to minor in the majority of poisonings (69-100%). For 34 individual patients (21 from our study and 13 from literature), detailed data on dose and clinical course were available to examine the dose-toxicity relationship. The median dose was significantly lower in the PSS none-minor group ("benign") (8.6 mg kg
conclusionsIn general, higher pregabalin doses result in more severe poisonings. Below 20 mg kg
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